The only kind of genetic conditions that karyomapping cannot detect are those that arise spontaneously, through a random mutation.

There are some leukodystrophies that do not appear to be inherited, but rather arise spontaneously.

Most pituitary tumors arise spontaneously and are not genetically inherited.

Although they usually occur at the site of an injury, keloids can also arise spontaneously.

Quark and lepton masses also break the electroweak gauge symmetries, so they, too, must arise spontaneously.