As with any habit, you need to increase the dosage to stay hooked, so the scale of the depravity increased.

For instance, patients undergoing long-term anticoagulation therapy with warfarin have to be especially cautious and increase their dosage of warfarin accordingly.

Take three drops three times daily for the first month, gradually increasing the dosage up to seven drops, three times daily.

So he increased his dosage ever so little, and again basked in that encompassing sense of euphoria.

The more you use, the higher your tolerance, which means users often end up increasing their dosage to get the same calm.