To take the plunge into independence would be an irreversible change in status.

By 2011, 25 per cent of residents were living in such accommodation, reflecting an apparently irreversible change that will spread nationwide in 2013.

Retinal undergoes an irreversible change in shape when it absorbs light.

The inhibitor binds covalently to the enzyme so that the substrate can no longer bind causing a permanent and irreversible change.

Their requirements are guided by transition management concepts and consider the fundamental and irreversible change in the culture, structure and practices of a system.

These allowed for more control over food production than had ever been imagined possible, with worldchanging and irreversible consequences.

These are errors with irreversible consequences.

It recommends deferring all non-trivial surgeries which have irreversible consequences.

Have potential long-term and irreversible consequences been seriously evaluated, and by whom?

Of all those who tampered with time, she was the only one who seemed concerned that what they had done may have had irreversible consequences.

That, at 30, an irreversible decline had set in.

In the 1950s the comic book was in steep, seemingly irreversible decline.

He had reached that point where a prolonged run of low scores will be interpreted as irreversible decline rather than a blip.

Some feel that sport has gone into irreversible decline since their own youth.

These days in professional snooker, rather than life beginning at 40, irreversible decline invariably sets in.

One of the volunteers was in a coma, with apparently irreversible loss of brain function.

The first of these, relaxation, leads to an irreversible loss of magnetisation.

This often resulted in irreversible loss of blood.

Although till now they are in majority in population but this brain drain has caused them irreversible loss.

Then the subsequent and irreversible loss of the unique identity.

If you take away too much of the forest it dries out - and this would potentially be an irreversible process.

The irreversible process will eventually destroy the object.

An irreversible process increases the entropy of the universe.

It was a very slow but irreversible process.

An irreversible process degrades the performance of a thermodynamic system, designed to do work or produce cooling, and results in entropy production.

But an affluent society breeds ever later and less, a seemingly irreversible trend.

However, this may not be an irreversible trend.

Now, he has to try to take on the most irreversible trend of them all.

It's a waste of time trying to buck an irreversible trend.