The treatments were relaxing, but of limited efficacy.

The use of gold compounds decreased since the 1990s because of numerous side effects and monitoring requirements, limited efficacy, and very slow onset of action.

These per process rulesets have limited efficacy in filtering every possible association that may occur with other processes.

Such treatment has been superseded as the best practice for treating the disease because of numerous side effects and monitoring requirements, their limited efficacy, and very slow onset of action.

Other techniques used with limited efficacy have been the polyculture of shrimp with tilapia and maintenance of near-optimal water quality conditions in the grow-out ponds with reduction of organic loading.