This is because taking it for too long can have the paradoxical effect of making bones more brittle.

His line gave the paradoxical effect of being at once tentative and confident.

And yet this reliance on the East had a paradoxical effect.

This paradoxical effect is uncanny, which is why the wolf is more disturbing than any other predator.

Some sedatives produce the paradoxical effect of making the person more anxious, excited or aggressive than he or she was in the first place.