Resulting animals with the genetic change in their germline cells can then often pass the gene knockout to future generations.

They can not pass the gene to the next generation.

Carriers are, however, able to pass the gene onto their offspring, who may then express the gene.

This might seem to defy evolutionary logic: in most mammals females die when they cannot directly pass their genes to a new generation.

My mum was devastated she passed the gene on to me.