Many more adults may have a passing intolerance to wheat, shown in bloating and abdominal discomfort.

Symptoms vary, but classically include a change in bowel habit (often looser), bloating, and abdominal discomfort - exacerbated by eating and relieved by going to the loo.

Symptoms included abdominal discomfort, bloated abdomen, and intestinal hurrying after meals.

They include malaise, headache, dizziness, abdominal discomfort, nausea, rise in temperature and occasionally allergic skin reactions.

Common adverse effects following administration include abdominal discomfort and nausea.