单词 | challenge study |
释义 | > as lemmaschallenge study 9. The action or process of administering an immunogenic agent to an animal or person in order to study the resulting immune response, or of exposing an animal or person to an infectious agent, esp. to measure the efficacy of a vaccine. Frequently as a modifier, esp. in challenge study, challenge trial. Cf. challenge v. 9. ΘΚΠ the world > health and disease > healing > medicines or physic > [noun] > dose of medicine > types of dose overdose1700 under-dose1822 challenge1935 booster1950 loading dose1961 bolus1967 1935 Canad. Public Health Jrnl. 26 213 When administered to guinea pigs previous to a challenge inoculation of Br[ucella] abortus, serum 43C conferred a degree of protection. 1952 Proc. Soc. Exper. Biol. & Med. 81 110/1 Even after 10 days a high mortality rate results following antigenic challenge of a series of mice sensitized with a mixture of horse serum and vaccine. 1964 W. G. Smith Allergy & Tissue Metabolism i. 5 The second injection of antigen, which brings about anaphylactic shock, is termed the challenge dose. 2001 J. M. Gwaltney & J. O. Hendley in J. C. Thomas & D. J. Weber Epidemiol. Methods Study Infectious Dis. x. 220/2 Most virus challenge studies have been done with rhinovirus and influenza virus. 2007 Jrnl. Infectious Dis. 196 1329 The vaccine provided mild immune protection to the ferrets after challenge. 2020 Gazette (Montreal) (Nexis) 19 May (Early ed.) a4 More than 23,000 volunteers from 102 countries have signed up online to participate in a human challenge trial for COVID-19 should one be held. < as lemmas |
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