That crushes; bruising, overwhelming, etc.

That breathes (in various senses of breathe, v.); esp. respiring; living.

That inflicts damage. (Of a task or activity) testing, demanding, exhausting; (of climate or conditions) harsh, injurious, oppressive.

That ‘winds’ one; taking one's breath away.

That ‘gruels’; exhausting, ‘punishing’.

Spiritually or mentally exhausting.