So as to cause suffering, hardship, or great straits; to a painful or distressing degree; severely, grievously, oppressively.

In such a manner as to press hardly or severely upon a person or thing.

So as to cause distress or suffering; grievously, harshly. Obsolete.

In a troublesome or vexatious manner; grievously, adversely. Obsolete.

In an afflictive manner; so as to distress; painfully, grievously, troublesomely.

In an afflicting manner; so as to distress or trouble.