Of pain, wounds, diseases, painful or destructive conditions: Cruel, terribly severe. Now only in weakened sense: cf. A. 2(b) A. 4b.

Severe, burdensome, oppressive. Of disease: acute, severe. Of pain, bodily convulsions, etc.: intense, violent, wrenching.

Of a disease, wound, or pain: Causing great suffering or danger; acute, severe. Now rare.

transferred. Of fever, thirst, etc.: Characterized by great heat, raging, violent.

Medicine. Of a disease, symptom, etc.: coming quickly to a crisis or conclusion; of rapid onset and short duration; of recent or sudden onset…

Malignant, virulent, harmful. Obsolete.

Of a disease: very acute or severe, and often rapidly fatal.

Causing or involving bodily pain; painful, grievous; distressing or severe in this respect. Of sickness.

Bad, in various senses (not always clearly distinguishable). Frequent in Middle English use; later… Of wounds, disease: severe; malignant.

Of a disease, etc.: = malignant, adj. 3a. disused.

Of pain, illness, etc.: severe; intense; virulent.

= malignant, adj.

Of disease, pain, etc.: severe, intense, violent.

Of an ill habit; malignant (as a disease).

Having a marked effect on the taste or other senses. Pungent, acrid, keen; (of a medicine) sharp or violent in operation; (of a disease, pain, or…

Medicine. Of diseases, etc.: Characterized by extreme malignancy or violence.

Originally (of a disease): potentially fatal; extremely severe; exceptionally contagious or infectious; incurable. Now chiefly (of a neoplasm)…

Of a disease or pain: violent.

Of a disease or pain: extremely violent. Cf. raging, adj. 2.

Of pains, diseases, evil influences: Raging, cruel. Obsolete.

Of something or someone unwelcome, harmful, etc.: widespread, prevalent, endemic; flourishing or spreading unchecked; spec. (of a disease) raging.

Of disease: violent, severe. Obsolete. rare.

Eager, impetuous, violent. Of an attack of disease: Acute, violent. †Also = acute, adj. 1.

Of drink: potent. Of a voice or cry: loud. Of a fit, a storm: violent. archaic.

Of a remedy: strong, powerful, efficacious. Obsolete.

Intensely or excessively acute.

Of an injury, condition, etc.: significant or worrying; giving cause for anxiety or concern; grave, threatening, or dangerous.

Of a disease: Malignant. rare.

Of something which is inherently unpleasant, painful, etc.: particularly serious, severe.

Of an attack of illness or disease: Attended with a maximum of pain or distress, violent.

Not favourable, in various senses. Of diseases, physical injuries, etc. Obsolete.

Now esp. in unfavourable sense, of faults, evils, difficulties, responsibilities, etc.: Highly serious, formidable. Of diseases or symptoms…