CRISPRn.

Brit.

/ˈkrɪspə/, U.S.

/ˈkrɪspər/

Forms: 2000s– CRISPR, 2000s– Crispr.

Origin: Formed within English, as an acronym. Etymon: English Clustered Regularly Interspaced Short Palindromic Repeats.

Etymology: Acronym < the initial letters of Clustered Regularly Interspaced Short Palindromic Repeats.

Biology.

a. A segment of prokaryotic DNA involved in the cell's defence mechanisms against viruses, consisting of short, repeating, palindromic base sequences interspersed with spacer sequences (spacer n.¹ 4) derived from a virus or plasmid that has previously attacked the cell. Frequently attributive.The spacers in CRISPR DNA allow it to encode RNAs that recognize such sequences in a foreign genome, at which sequences the RNA molecules bind in a complex with associated proteins that act as molecular scissors and cut the genomic DNA.

ΚΠ

2002 Molecular Microbiol. 43 1567/1 A characteristic of the CRISPRs, not seen in any other class of repetitive DNA, is that the repeats of the CRISPRs are interspaced by similarly sized non-repetitive DNA.

2006 E. V. Koonin et al. in N. A. Logan et al. Prokaryotic Diversity 53 We speculate that CRISPR regions are transcribed from a promoter located in the AT-rich CRISPR leader.

2010 Proc. Royal Soc. B. 277 2100/2 CRISPR-mediated resistance is explicitly linked to genetic variance in the prevailing pathogen population.

2014 New Scientist 25 Jan. 42/3 The CRISPR system can be seen as a form of Lamarckian evolution—an adaptation acquired during an individual's lifetime is passed onto its offspring.

b. Any of various genomic engineering techniques incorporating a CRISPR sequence of DNA and its associated proteins and RNA, used in gene editing and regulation.

ΚΠ

2013 Independent 7 Nov. 1/2 For the first time, scientists are able to engineer any part of the human genome with extreme precision using a revolutionary new technique called Crispr.

2015 J. Mitteldorf in A. I. Yashin & S. Michal Jazwinski Aging & Health 60 CRISPR may provide a dramatic shortcut,..permitting us to target genes for promotion or repression.

2015 Garden City (Kansas) Telegram 8 May a4 The technique, known as CRISPR, is faster and cheaper than other gene-editing practices; but it has stirred a firestorm of controversy.

This is a new entry (OED Third Edition, September 2016; most recently modified version published online March 2022).

单词	crispr
释义	CRISPRn. Brit. /ˈkrɪspə/, U.S. /ˈkrɪspər/ Forms: 2000s– CRISPR, 2000s– Crispr. Origin: Formed within English, as an acronym. Etymon: English Clustered Regularly Interspaced Short Palindromic Repeats. Etymology: Acronym < the initial letters of Clustered Regularly Interspaced Short Palindromic Repeats. Biology. a. A segment of prokaryotic DNA involved in the cell's defence mechanisms against viruses, consisting of short, repeating, palindromic base sequences interspersed with spacer sequences (spacer n.¹ 4) derived from a virus or plasmid that has previously attacked the cell. Frequently attributive.The spacers in CRISPR DNA allow it to encode RNAs that recognize such sequences in a foreign genome, at which sequences the RNA molecules bind in a complex with associated proteins that act as molecular scissors and cut the genomic DNA. ΚΠ 2002 Molecular Microbiol. 43 1567/1 A characteristic of the CRISPRs, not seen in any other class of repetitive DNA, is that the repeats of the CRISPRs are interspaced by similarly sized non-repetitive DNA. 2006 E. V. Koonin et al. in N. A. Logan et al. Prokaryotic Diversity 53 We speculate that CRISPR regions are transcribed from a promoter located in the AT-rich CRISPR leader. 2010 Proc. Royal Soc. B. 277 2100/2 CRISPR-mediated resistance is explicitly linked to genetic variance in the prevailing pathogen population. 2014 New Scientist 25 Jan. 42/3 The CRISPR system can be seen as a form of Lamarckian evolution—an adaptation acquired during an individual's lifetime is passed onto its offspring. b. Any of various genomic engineering techniques incorporating a CRISPR sequence of DNA and its associated proteins and RNA, used in gene editing and regulation. ΚΠ 2013 Independent 7 Nov. 1/2 For the first time, scientists are able to engineer any part of the human genome with extreme precision using a revolutionary new technique called Crispr. 2015 J. Mitteldorf in A. I. Yashin & S. Michal Jazwinski Aging & Health 60 CRISPR may provide a dramatic shortcut,..permitting us to target genes for promotion or repression. 2015 Garden City (Kansas) Telegram 8 May a4 The technique, known as CRISPR, is faster and cheaper than other gene-editing practices; but it has stirred a firestorm of controversy. This is a new entry (OED Third Edition, September 2016; most recently modified version published online March 2022). < n.2002
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