cytostaticadj.n.

Brit.

/ˌsʌɪtə(ʊ)ˈstatɪk/, U.S.

/ˌsaɪdəˈstædɪk/

Origin: Formed within English, by compounding. Etymons: cyto- comb. form, -static comb. form.

Etymology: < cyto- comb. form + -static comb. form. With senses A. 2 and B., compare earlier bacteriostatic adj. at bacteriostasis n. Derivatives.

Biology.

A. adj.

†1. Designating or relating to a quiescent or non-motile state of a cell. Cf. cytokinetic adj. Obsolete. rare.

ΚΠ

1893 Proc. Amer. Philos. Soc. 31 196 The alternating periods of quiescence of Amœba are cytostatic; its spherical form in the encysted condition is the result of a perfect cytostatic equilibrium in every direction.

2. That inhibits the proliferation or growth of cells, esp. tumour cells; of or relating to such inhibition. Cf. cytotoxic adj. 1.

ΚΠ

1949 Lancet 19 Nov. 971/1 The second day's discussion concerned anti-mitotic and cytostatic substances.

1971 Times 4 Aug. 12/6 A few years ago Dr Roe obtained great satisfaction from her discovery of the cytostatic properties of tragacanth gum.

1992 R. C. Rees & H. Parry in C. E. Lewis & J. O'D. McGee Macrophage viii. 335 Monocytes and macrophages often display potent cytostatic and cytotoxic activity towards tumour cells.

2008 Breast 17 239/2 Their character, more cytostatic than cytotoxic, has made their clinical development difficult.

B. n.

A cytostatic agent.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > other stimulators or inhibitors > [noun]

styptica1400

carrier1844

luciferase1888

luciferin1888

urease1892

peroxidase1899

protease1903

renin1903

phenolase1907

proteinase1907

phytase1908

lecithinase1910

uricase1910

phosphatase1912

prunase1912

phenoloxidase1913

oxytocin1927

phosphomonoesterase1932

androgen1936

phosphorylase1939

slow reacting substance1939

phospholipase1945

plasmin1945

bradykinin1949

nitroreductase1953

cytostatic1964

oncogen1967

autoinducer1968

1964 Biochem. Pharmacol. 13 1663 (title) The action of some cytostatics on the hexose monophosphate shunt and glycolysis in experimental rat tumours.

1970 Times 23 June 26/5 (advt.) In the field of anaesthetics, anticonvulsants, antihistamines and cytostatics FBA is one of the acknowledged leaders.

2000 G. Hautmann et al. in L. E. Millikan Drug Therapy in Dermatol. vi. 111 All cytostatics are toxic to healthy body cells, especially to rapidly proliferating tissues.

This is a new entry (OED Third Edition, November 2010; most recently modified version published online March 2022).

单词	cytostatic
释义	cytostaticadj.n. Brit. /ˌsʌɪtə(ʊ)ˈstatɪk/, U.S. /ˌsaɪdəˈstædɪk/ Origin: Formed within English, by compounding. Etymons: cyto- comb. form, -static comb. form. Etymology: < cyto- comb. form + -static comb. form. With senses A. 2 and B., compare earlier bacteriostatic adj. at bacteriostasis n. Derivatives. Biology. A. adj. †1. Designating or relating to a quiescent or non-motile state of a cell. Cf. cytokinetic adj. Obsolete. rare. ΚΠ 1893 Proc. Amer. Philos. Soc. 31 196 The alternating periods of quiescence of Amœba are cytostatic; its spherical form in the encysted condition is the result of a perfect cytostatic equilibrium in every direction. 2. That inhibits the proliferation or growth of cells, esp. tumour cells; of or relating to such inhibition. Cf. cytotoxic adj. 1. ΚΠ 1949 Lancet 19 Nov. 971/1 The second day's discussion concerned anti-mitotic and cytostatic substances. 1971 Times 4 Aug. 12/6 A few years ago Dr Roe obtained great satisfaction from her discovery of the cytostatic properties of tragacanth gum. 1992 R. C. Rees & H. Parry in C. E. Lewis & J. O'D. McGee Macrophage viii. 335 Monocytes and macrophages often display potent cytostatic and cytotoxic activity towards tumour cells. 2008 Breast 17 239/2 Their character, more cytostatic than cytotoxic, has made their clinical development difficult. B. n. A cytostatic agent. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > other stimulators or inhibitors > [noun] styptica1400 carrier1844 luciferase1888 luciferin1888 urease1892 peroxidase1899 protease1903 renin1903 phenolase1907 proteinase1907 phytase1908 lecithinase1910 uricase1910 phosphatase1912 prunase1912 phenoloxidase1913 oxytocin1927 phosphomonoesterase1932 androgen1936 phosphorylase1939 slow reacting substance1939 phospholipase1945 plasmin1945 bradykinin1949 nitroreductase1953 cytostatic1964 oncogen1967 autoinducer1968 1964 Biochem. Pharmacol. 13 1663 (title) The action of some cytostatics on the hexose monophosphate shunt and glycolysis in experimental rat tumours. 1970 Times 23 June 26/5 (advt.) In the field of anaesthetics, anticonvulsants, antihistamines and cytostatics FBA is one of the acknowledged leaders. 2000 G. Hautmann et al. in L. E. Millikan Drug Therapy in Dermatol. vi. 111 All cytostatics are toxic to healthy body cells, especially to rapidly proliferating tissues. This is a new entry (OED Third Edition, November 2010; most recently modified version published online March 2022). < adj.n.1893
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