cycloheximiden.

Brit.

/ˌsʌɪklə(ʊ)ˈhɛksɪmʌɪd/, U.S.

/ˌsaɪkloʊˈhɛksəˌmaɪd/

Origin: Formed within English, by compounding. Etymons: cyclo- comb. form, hexyl n., imide n.

Etymology: < cyclo- comb. form + hex- (in hexyl n.) + imide n.

Pharmacology.

A compound with antibiotic activity produced by the streptomycete bacterium Streptomyces griseus, now used mainly as an inhibitor of protein synthesis in experimental systems. Also called actidione.Chemical name: 3-[2-(3, 5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-glutarimide; C₁₅H₂₃NO₄.

ΚΠ

1950 Mycologia 42 253 Cycloheximide has been assigned as the generic name for the compound β-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-glutarimide for which The Upjohn Company adopted ‘Acti-dione’ as its trademark.

1976 Sci. Amer. July 51/1 Small implants of actinomycin D and cycloheximide in the preoptic area of the rat brain reversibly block the facilitation of female sexual behavior.

1991 EMBO Jrnl. 9 2861/2 We have manipulated the physiological state of culture mouse cells by..inhibiting cellular protein synthesis by cycloheximide.

2009 W. G. Hopkins & N. P. A. Hüner Introd. Plant Physiol. (ed. 4) xviii. 317/2 Many of these responsive genes could also be induced by the protein synthesis inhibitor cycloheximide.

This is a new entry (OED Third Edition, March 2013; most recently modified version published online March 2022).

单词	cycloheximide
释义	cycloheximiden. Brit. /ˌsʌɪklə(ʊ)ˈhɛksɪmʌɪd/, U.S. /ˌsaɪkloʊˈhɛksəˌmaɪd/ Origin: Formed within English, by compounding. Etymons: cyclo- comb. form, hexyl n., imide n. Etymology: < cyclo- comb. form + hex- (in hexyl n.) + imide n. Pharmacology. A compound with antibiotic activity produced by the streptomycete bacterium Streptomyces griseus, now used mainly as an inhibitor of protein synthesis in experimental systems. Also called actidione.Chemical name: 3-[2-(3, 5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-glutarimide; C₁₅H₂₃NO₄. ΚΠ 1950 Mycologia 42 253 Cycloheximide has been assigned as the generic name for the compound β-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-glutarimide for which The Upjohn Company adopted ‘Acti-dione’ as its trademark. 1976 Sci. Amer. July 51/1 Small implants of actinomycin D and cycloheximide in the preoptic area of the rat brain reversibly block the facilitation of female sexual behavior. 1991 EMBO Jrnl. 9 2861/2 We have manipulated the physiological state of culture mouse cells by..inhibiting cellular protein synthesis by cycloheximide. 2009 W. G. Hopkins & N. P. A. Hüner Introd. Plant Physiol. (ed. 4) xviii. 317/2 Many of these responsive genes could also be induced by the protein synthesis inhibitor cycloheximide. This is a new entry (OED Third Edition, March 2013; most recently modified version published online March 2022). < n.1950
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