diguaniden.

/ˈdʌɪɡwanʌɪd/

Etymology: < di- comb. form + -guanid- + -e (in guanidine n.

Chemistry.

a. A colourless crystalline compound, NH[C(NH)NH₂]₂, which is a condensation product of two guanidine molecules with the loss of a molecule of ammonia; guanylguanidine.

ΚΠ

1910 Jrnl. Chem. Soc. 98 i. 896 Diguanide NH[C(NH₂):NH]₂, crystallises from absolute alchohol in glistening prisms, m. p. 130°.

1928 G. M. Dyson Chem. Chemotherapy v. 95 Several guanidine derivatives..can be considered pharmacologically inactive... Thus, guanyl urea (315)..is inactive and diguanide (316) in the form of its hydrochloride is inactive.

1946 Nature 16 Nov. 707/2 The diguanide system..provided structural features similar to those found in the earlier active pyrimidine compound ‘2666’.

1952 Morton & Hoggarth in E. H. Rodd Chem. Carbon Compounds I b. xiv. 935 Diguanide itself is a strongly basic substance.

b. Any compound derived from diguanide by replacement of hydrogen atoms by other atoms or groups; also, a diguanidine.

ΚΠ

1911 Jrnl. Chem. Soc. 100 i. 928 Diguanides of the type NH:C(NHR)·NH·C(NH₂):NH, where R = aryl, are readily obtained in the form of their hydrochlorides by heating dicyanodiamide with the hydrochlorides of aromatic amines in aqueous solution.

1961 Lancet 9 Sept. 563/2 The present compounds are not diguanides like synthalin.

1961 [see ].

1966 New Scientist 24 Nov. 433/1 The longing of diabetics for a hypoglycaemic drug which could be taken orally..was realized ten years ago when the sulphonylureas and diguanides were introduced.

This entry has not yet been fully updated (first published 1972; most recently modified version published online June 2018).

单词	diguanide
释义	diguaniden. /ˈdʌɪɡwanʌɪd/ Etymology: < di- comb. form + -guanid- + -e (in guanidine n. Chemistry. a. A colourless crystalline compound, NH[C(NH)NH₂]₂, which is a condensation product of two guanidine molecules with the loss of a molecule of ammonia; guanylguanidine. ΚΠ 1910 Jrnl. Chem. Soc. 98 i. 896 Diguanide NH[C(NH₂):NH]₂, crystallises from absolute alchohol in glistening prisms, m. p. 130°. 1928 G. M. Dyson Chem. Chemotherapy v. 95 Several guanidine derivatives..can be considered pharmacologically inactive... Thus, guanyl urea (315)..is inactive and diguanide (316) in the form of its hydrochloride is inactive. 1946 Nature 16 Nov. 707/2 The diguanide system..provided structural features similar to those found in the earlier active pyrimidine compound ‘2666’. 1952 Morton & Hoggarth in E. H. Rodd Chem. Carbon Compounds I b. xiv. 935 Diguanide itself is a strongly basic substance. b. Any compound derived from diguanide by replacement of hydrogen atoms by other atoms or groups; also, a diguanidine. ΚΠ 1911 Jrnl. Chem. Soc. 100 i. 928 Diguanides of the type NH:C(NHR)·NH·C(NH₂):NH, where R = aryl, are readily obtained in the form of their hydrochlorides by heating dicyanodiamide with the hydrochlorides of aromatic amines in aqueous solution. 1961 Lancet 9 Sept. 563/2 The present compounds are not diguanides like synthalin. 1961 [see ]. 1966 New Scientist 24 Nov. 433/1 The longing of diabetics for a hypoglycaemic drug which could be taken orally..was realized ten years ago when the sulphonylureas and diguanides were introduced. This entry has not yet been fully updated (first published 1972; most recently modified version published online June 2018). < n.1910
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