dicoumarinn.
/dʌɪˈkuːmərɪn/ Chemistry.
Originally: any compound with a structure based on two coumarin molecules joined together. Now spec. the compound 3,3′-methylenebis-(4-hydroxycoumarin), C19H12 O6, a white powder first isolated from spoiled sweet clover as the cause of hæmorrhage in sweet clover poisoning of cattle and later prepared synthetically and used as an anti-coagulant.
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1886 Jrnl. Chem. Soc. 50 47 Salicylaldehyde and succinic aldehyde yield a dicoumarin..very similar in chemical behaviour to coumarin.
1941 Jrnl. Biol. Chem. 138 526 The hemorrhagic agent..present in improperly cured hay made from the common sweet clovers..is the dicoumarin, 3,3′-methylenebis (4-hydroxycoumarin).
1943 Acta Physiol. Scand. VI. 28 The author has presented data on the prothrombin depressing effect in animals and man of a dicoumarin..first isolated from moulded sweet clover hay.
1947 tr. J. Schmidt Text-bk. Org. Chem. (ed. 5) ii. xi. 475 The clinical value of dicoumarin is enhanced by its lasting effect and the fact that it can be taken orally.
1965 New Scientist 22 Apr. 245/2 The greatest advance in effective rodenticides was the development of the anti-coagulants such as dicoumarin.
This entry has not yet been fully updated (first published 1972; most recently modified version published online March 2019).
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