disulfiramn.

Brit.

/dʌɪˈsʌlfɪram/, U.S.

/daɪˈsəlfəˌræm/

Origin: Formed within English, by compounding. Etymons: English disulfide , disulphide n., thiuram n.

Etymology: < disulfi- (in disulfide, variant of disulphide n.) + -ram (in thiuram n.), elements of the chemical name.

Pharmacology.

A drug that alters the metabolism of alcohol to produce unpleasant effects such as flushing, breathlessness, and palpitations, and hence is used in the treatment of alcoholism.Disulfiram was originally developed for use as an additive in the rubber industry; the unpleasant effects of its interaction with alcohol were discovered accidentally.A proprietary term for this drug is Antabuse n.Chemical name: tetraethylthiuram disulphide; (C₂H₅)₂NCSSCN(C₂H₅)₂.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for alcoholism

disulfiram1946

Antabuse1948

perphenazine1957

oxazepam1964

1946 B. Heilesen Stud. Acarus Scabiei & Scabies in Acta Dermato-venereologica 26 Suppl. No. 14. iii. 249 With the Danish preparation ‘Disulfiram’..the writer has found 2 relapse cases out of 20 patients.

1952 Brit. Med. Jrnl. 22 Nov. 1146/2 The Pharmacopoeia Commission has issued the following Supplementary List of Approved Names:..Disulfiram (tetraethylthiuram disulphide, ‘antabuse’).

1968 Brit. Jrnl. Psychiatry 114 1028/2 Disulfiram proved useful not only as a deterrent from drinking but as a measure of commitment to the treatment.

1991 Lancet 5 Jan. 60/1 Disulfiram and calcium carbimide have been widely used to deter alcohol intake; they inhibit the enzyme aldehyde dehydrogenase which metabolises acetaldehyde to acetic acid.

2000 J. Mann Murder, Magic, & Med. (rev. ed.) ii. 53 The effects are similar to those experienced with the drug disulfiram (Antabuse), which is used to treat alcoholics, the idea being that unpleasant sensations are then associated with the consumption of alcohol.

This is a new entry (OED Third Edition, June 2016; most recently modified version published online March 2022).

单词	disulfiram
释义	disulfiramn. Brit. /dʌɪˈsʌlfɪram/, U.S. /daɪˈsəlfəˌræm/ Origin: Formed within English, by compounding. Etymons: English disulfide , disulphide n., thiuram n. Etymology: < disulfi- (in disulfide, variant of disulphide n.) + -ram (in thiuram n.), elements of the chemical name. Pharmacology. A drug that alters the metabolism of alcohol to produce unpleasant effects such as flushing, breathlessness, and palpitations, and hence is used in the treatment of alcoholism.Disulfiram was originally developed for use as an additive in the rubber industry; the unpleasant effects of its interaction with alcohol were discovered accidentally.A proprietary term for this drug is Antabuse n.Chemical name: tetraethylthiuram disulphide; (C₂H₅)₂NCSSCN(C₂H₅)₂. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for alcoholism disulfiram1946 Antabuse1948 perphenazine1957 oxazepam1964 1946 B. Heilesen Stud. Acarus Scabiei & Scabies in Acta Dermato-venereologica 26 Suppl. No. 14. iii. 249 With the Danish preparation ‘Disulfiram’..the writer has found 2 relapse cases out of 20 patients. 1952 Brit. Med. Jrnl. 22 Nov. 1146/2 The Pharmacopoeia Commission has issued the following Supplementary List of Approved Names:..Disulfiram (tetraethylthiuram disulphide, ‘antabuse’). 1968 Brit. Jrnl. Psychiatry 114 1028/2 Disulfiram proved useful not only as a deterrent from drinking but as a measure of commitment to the treatment. 1991 Lancet 5 Jan. 60/1 Disulfiram and calcium carbimide have been widely used to deter alcohol intake; they inhibit the enzyme aldehyde dehydrogenase which metabolises acetaldehyde to acetic acid. 2000 J. Mann Murder, Magic, & Med. (rev. ed.) ii. 53 The effects are similar to those experienced with the drug disulfiram (Antabuse), which is used to treat alcoholics, the idea being that unpleasant sensations are then associated with the consumption of alcohol. This is a new entry (OED Third Edition, June 2016; most recently modified version published online March 2022). < n.1946
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