allotypyn.

Brit.

/ˈaləˌtʌɪpi/, U.S.

/ˈæləˌtaɪpi/

Origin: A borrowing from French. Etymon: French allotypie.

Etymology: < French allotypie (J. Oudin 1956, in Compt. rend. de l'Acad. des Sci. 242 2606) < allo- allo- comb. form + type type n. + -ie -y suffix³.

Immunology.

The occurrence of an immunoglobulin or other protein in genetically determined, antigenically distinct forms in different members of the same species.

ΚΠ

1956 Science 29 June 1167/1 Oudin has proposed the name allotypy for this phenomenon.

1962 Nature 19 May 658/2 It would be of interest to determine if antigenic polymorphisms of β-lipoproteins (allotypy) occur in species other than man; for example, in rabbits, where allotypy for the α- and β-globulin has already been reported.

1972 Sci. Amer. June 35/1 The immunoglobulin molecule consists of a ‘constant’ region whose amino acid composition varies among different individuals of the same species. This variation, known as allotypy, is not related to the molecule's recognition function in its role as an antibody.

2000 Vet. Immunol. & Immunopathol. 73 287 We show here that this very strong breed dependency of IgA allotypy in swine can produce a sample bias.

This entry has been updated (OED Third Edition, September 2012; most recently modified version published online December 2021).

单词	allotypy
释义	allotypyn. Brit. /ˈaləˌtʌɪpi/, U.S. /ˈæləˌtaɪpi/ Origin: A borrowing from French. Etymon: French allotypie. Etymology: < French allotypie (J. Oudin 1956, in Compt. rend. de l'Acad. des Sci. 242 2606) < allo- allo- comb. form + type type n. + -ie -y suffix³. Immunology. The occurrence of an immunoglobulin or other protein in genetically determined, antigenically distinct forms in different members of the same species. ΚΠ 1956 Science 29 June 1167/1 Oudin has proposed the name allotypy for this phenomenon. 1962 Nature 19 May 658/2 It would be of interest to determine if antigenic polymorphisms of β-lipoproteins (allotypy) occur in species other than man; for example, in rabbits, where allotypy for the α- and β-globulin has already been reported. 1972 Sci. Amer. June 35/1 The immunoglobulin molecule consists of a ‘constant’ region whose amino acid composition varies among different individuals of the same species. This variation, known as allotypy, is not related to the molecule's recognition function in its role as an antibody. 2000 Vet. Immunol. & Immunopathol. 73 287 We show here that this very strong breed dependency of IgA allotypy in swine can produce a sample bias. This entry has been updated (OED Third Edition, September 2012; most recently modified version published online December 2021). < n.1956
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