Alzheimern.

1911 Physician & Surgeon 33 337 Doctor Barrett reported a case resembling Alzheimer's disease, in which placques were found scattered through the brain associated with a peculiar neurofibril degeneration.

1955 H. H. Merritt Textbk. Neurol. vi. 417 The microscopic changes in Alzheimer's disease are somewhat similar to those which occur with senility.

1994 London (Ont.) Free Press 23 July (Regional ed.) d9/1 Most cases [of senility or dementia] are caused by the incurable and continually degenerative Alzheimer disease.

2005 Washington Post 1 Feb. (Home ed.) a9/4 A highly sensitive new test could someday lead to a different way to diagnose Alzheimer's disease.

1911 Proc. Amer. Medico-psychol. Assoc. 67th Ann. Meeting 172 Where Alzheimer degeneration is advanced indications of cell devastation..are seen in corresponding Nissl preparations from the same regional areas.

1940 Amer. Jrnl. Orthopsychiatry 10 70 Even when a Pick patient has progressed to some extent,..it can be demonstrated that in contrast to Alzheimer patients, memory is still relatively well preserved.

1955 H. H. Merritt Textbk. Neurol. vi. 417 There is a diffuse loss of cells in all layers of the cortex, secondary gliosis, argentophile plaques (Alzheimer plaques) and neurofibrillar degeneration.

1991 Chicago Tribune 15 Aug. a19/2 Autopsy studies on Alzheimer's brains..show that in addition to the beta amyloid plaques outside of brain cells, there are tangles inside the nerve cells.

2009 New Yorker 27 Apr. 35/3 Another class of drugs, cholinesterase inhibitors..are already being used with some success to treat Alzheimer's patients.

1911 Proc. Amer. Medico-psychol. Assoc. 67th Ann. Meeting 117 Barrett (1911) describes the..anatomical findings in 8 elderly subjects coming to autopsy in which plaques were found, 7 of the cases presenting the Alzheimer type of intracellular neurofibril degeneration.

1934 Brain 57 135 The Alzheimer type of fibrillary alteration is also constant in senile dementia.

1977 Jrnl. Neurol. Sci. 34 263 This finding may be of interest in relation to the electron-microscopic studies in Alzheimer-type dementia which indicate pre-synaptic terminal abnormalities.

2009 Jrnl. Neurol. Sci. 283 44/1 To understand the respective role of Alzheimer's disease and cerebrovascular disease is crucial in order to develop an optimal therapeutic strategy in dementia of the Alzheimer's type.

1938 Lancet 21 May 1166/1 Generally speaking Alzheimer's was a disease of the posterior part of the hemisphere, Pick's of the anterior.

1957 J. R. Ewalt et al. Pract. Clin. Psychiatry (ed. 8) xi. 152 Huntingdon's chorea is more common than either Pick's or Altzheimer's [sic].

1984 A. Hailey Strong Med. II. viii. 165 ‘Alzheimer's,’ Celia said. ‘That's when the brain stops functioning isn't it?’ Lord nodded. ‘Part of the brain. Memory disappears.’

2008 Whole Dog Jrnl. Dec. 10/1 Should our dogs wander in the same fashion, it could well be a sign of cognitive dysfunction syndrome (CDS), a condition quite similar to Alzheimer's in humans.

1940 Amer. Jrnl. Orthopsychiatry 10 70 The memory defect in Alzheimer is valuable for the diagnostic differentiation from another presenile deterioration, namely, Pick's disease.

1954 W. Mayer-Gross et al. Clin. Psychiatry xi. 455 In Alzheimer it might be either some exogenous toxin..or a large number of genes each of small effect.

2007 Chicago Tribune (Midwest ed.) 11 Nov. x. 25/2 The big A, Alzheimer, has taken over my own generation.