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endonuclease
endonuclease n. 
/ˌɛndoʊˈn(j)ukliˌeɪs/ Biochemistry any enzyme that cleaves a polynucleotide chain by separating nucleotides other than the two end ones; cf. exo- prefix.
Brit. /ˌɛndə(ʊ)ˈnjuːklɪeɪz/
, /ˌɛndə(ʊ)ˈnjuːklɪeɪz/U.S. /ˌɛndoʊˈn(j)ukliˌeɪz/
, /ˌɛndoʊˈn(j)ukliˌeɪz//ˌɛndoʊˈn(j)ukliˌeɪs/ΚΠ
1962 Jrnl. Biol. Chem. 237 819/1 This enzyme produces scissions at many points along the deoxyribonucleic acid chain and hence can be classed as an endonuclease.
1982 T. M. Devlin Textbk. Biochem. xvii. 802 Some endonucleases have been particularly useful in the development of early methodologies for sequencing of RNA polynucleotides.
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