epigeneticsn.

Brit.

/ˌɛpᵻdʒᵻˈnɛtɪks/, U.S.

/ˌɛpədʒənˈɛdɪks/

Origin: Formed within English, by conversion. Etymon: epigenetic adj.

Etymology: < epigenetic adj.: see -ic suffix 2.

Biology and Molecular Biology.

With singular agreement. The scientific study of the causal mechanisms of the development and differentiation of cells and organisms; (now usually) spec. the study of (esp. heritable) phenotypic changes that involve alteration or regulation of gene expression rather than changes in DNA sequence, and of the cellular and molecular processes responsible for these; the branch of biology concerned with this.Mechanisms that produce such changes in gene expression include the modification of chromosomal regions through the addition of methyl groups and the activation of silencer sequences in DNA.

ΚΠ

1942 C. H. Waddington in Endeavour 1 18/2 The..more important part of the task is to discover the causal mechanisms at work, and to relate them as far as possible to what experimental embryology has already revealed of the mechanics of development. We might use the name ‘epigenetics’ for such studies, thus emphasizing their relation to the concepts, so strongly favourable to the classical theory of epigenesis, which have been reached by the experimental embryologists.

1961 Amer. Naturalist 95 242 Epigenetics re-emphasizes a basic distinction between genotype and phenotype, between stored information and the expression of information... Thus, in addition to code sequence of nucleotides, other chromosomal differentiations having hereditary persistence are likely.

2003 N.Y. Times 7 Oct. (Washington Final ed.) d1/2 The research is a milestone in the relatively new science of epigenetics, the study of how environmental factors like diet, stress and maternal nutrition can change gene function without altering the DNA sequence in any way.

2014 Y.-X. Pan et al. in E. Ho & F. Domann Nutrition & Epigenetics 94 Epigenetics is a mechanism for storing and preserving a ‘molecular memory’ at the cellular level.

This entry has been updated (OED Third Edition, December 2021).

单词	epigenetics
释义	epigeneticsn. Brit. /ˌɛpᵻdʒᵻˈnɛtɪks/, U.S. /ˌɛpədʒənˈɛdɪks/ Origin: Formed within English, by conversion. Etymon: epigenetic adj. Etymology: < epigenetic adj.: see -ic suffix 2. Biology and Molecular Biology. With singular agreement. The scientific study of the causal mechanisms of the development and differentiation of cells and organisms; (now usually) spec. the study of (esp. heritable) phenotypic changes that involve alteration or regulation of gene expression rather than changes in DNA sequence, and of the cellular and molecular processes responsible for these; the branch of biology concerned with this.Mechanisms that produce such changes in gene expression include the modification of chromosomal regions through the addition of methyl groups and the activation of silencer sequences in DNA. ΚΠ 1942 C. H. Waddington in Endeavour 1 18/2 The..more important part of the task is to discover the causal mechanisms at work, and to relate them as far as possible to what experimental embryology has already revealed of the mechanics of development. We might use the name ‘epigenetics’ for such studies, thus emphasizing their relation to the concepts, so strongly favourable to the classical theory of epigenesis, which have been reached by the experimental embryologists. 1961 Amer. Naturalist 95 242 Epigenetics re-emphasizes a basic distinction between genotype and phenotype, between stored information and the expression of information... Thus, in addition to code sequence of nucleotides, other chromosomal differentiations having hereditary persistence are likely. 2003 N.Y. Times 7 Oct. (Washington Final ed.) d1/2 The research is a milestone in the relatively new science of epigenetics, the study of how environmental factors like diet, stress and maternal nutrition can change gene function without altering the DNA sequence in any way. 2014 Y.-X. Pan et al. in E. Ho & F. Domann Nutrition & Epigenetics 94 Epigenetics is a mechanism for storing and preserving a ‘molecular memory’ at the cellular level. This entry has been updated (OED Third Edition, December 2021). < n.1942
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