genotoxicadj.
/ˌdʒɛnə(ʊ)ˈtɒksɪk/, /ˌdʒiːnə(ʊ)ˈtɒksɪk/, U.S. /ˌdʒɛnoʊˈtɑksɪk/, /ˌdʒinoʊˈtɑksɪk/ Biology and Medicine.
That causes (usually irreversible) damage to or alteration of nucleic acids or chromosomes.
ΘΚΠ
the world > physical sensation > use of drugs and poison > poison > [adjective] > specific
botulinum1910
pesticidal1937
fungitoxic1945
embryotoxic1949
lathyrogenic1958
scombrotoxic1967
genotoxic1973
1973 H. Druckrey in Xenobiotica 3 298 Accordingly, carcinogens are ‘genotoxic’.
1974 Mutation Res. 25 197 The wide variety of genetic alterations that can be induced in human populations when exposed to chemical genotoxic substances..may be predictable using laboratory organisms such as yeasts.
1983 D. J. Snodin & J. W. Daniel in T. H. Grenby et al. Devel. Sweeteners—2 vi. 166 The concepts of batteries and tiers of tests have evolved in order to reduce the possibility that a genotoxic compound will avoid detection.
1997 Daily Tel. 22 Sept. 32/2 Just have one 250 gram helping per week of mushrooms, which contain a potent genotoxic carcinogenic hydrazine derivative called agaritine.
Derivatives
genotoxˈicity n.
ΘΚΠ
the world > physical sensation > use of drugs and poison > poison > [noun] > quality of being poisonous > specific
fungitoxicity1945
hepatotoxicity1952
nephrotoxicity1957
embryotoxicity1964
mycotoxicity1969
genotoxicity1978
1978 Mutation Res. 53 278 The genotoxicity of hair-dye constituents.
1988 Nature 28 Apr. 782/3 For the low genotoxic carcinogens that are negative in the Ames test..the authors recommend a second genotoxicity assay.
2000 Daily Tel. 7 June 3/6 The MDA had found that the implants could break down leading to genotoxicity that could cause malformation in foetuses.
This entry has been updated (OED Third Edition, June 2008; most recently modified version published online March 2022).
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adj.1973