glucostaticadj.
/ɡl(j)uːkəʊˈstatɪk/ Physiology.
Pertaining to or designating a mechanism for the maintenance of a fixed blood glucose level; spec. applied to a theory of metabolism which postulates such a mechanism.
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glucostatic1952
lente1977
1952 Mayer & Bates in Amer. Jrnl. Physiol. 168 817 An increase in blood sugar caused by glucose administration will normally cause an insulin response... A decrease in blood sugar, conversely, will induce greater secretion of glucose by the liver and increase the rate of gluconeogenesis. The experimental results presented here might be taken to support the concept of a ‘glucostatic’ scheme of the regulation of food intake.
1955 Ann. N.Y. Acad. Sci. 63 40 Because of the interrelationship of carbohydrate and fat metabolism, the lipostatic hypothesis could be integrated with the glucostatic mechanism.
1974 Nature 25 Oct. 710/1 A direct signal from fat stores to the brain has been postulated but an alternative is the modulation of a short term ‘glucostatic’ signal by a ‘lipostatic’ signal.
1983 Gen. & Compar. Endocrinol. 50 379 It appears that the glucostatic function of insulin evolved quite recently.
This entry has not yet been fully updated (first published 1993; most recently modified version published online June 2018).
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