glyoxalasen.
/ɡlʌɪˈɒksəleɪz//ɡlʌɪˈɒksəleɪs/ Biochemistry.
Either of two enzymes which together convert methylglyoxal to lactic acid in the presence of glutathione; originally considered a single enzyme.
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1913 Dakin & Dudley in Jrnl. Biol. Chem. 14 423 The catalyst..effects the rapid conversion of methyl glyoxal into lactic acid... We propose that it be named ‘glyoxalase’.
1951 Dakin & Dudley in Jrnl. Biol. Chem. 190 685 The first step consists in a condensation reaction between methylglyoxal and glutathione catalyzed by an enzyme referred to in this paper as glyoxalase I. This condensation product, in a second step which is catalyzed by glyoxalase II, is then broken down into glutathione and lactic acid.
1961 Biochem. Jrnl. 79 481/1 Ophthalmic acid..was a competitive inhibitor in the reaction catalysed by glyoxalase I.
This entry has not yet been fully updated (first published 1972; most recently modified version published online March 2019).
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