granulocyten.
/ˈɡranjʊləʊsʌɪt/ Medicine.
Any cell that contains or is destined to contain (conspicuous) granules in its cytoplasm; spec. any of the mature granular leucocytes (comprising neutrophils, eosinophils, and basophils) or the immature precursors of these cells.
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the world > life > the body > vascular system > blood > components of blood > blood corpuscle or plate > [noun] > white cells or corpuscles
white corpuscle1823
white cell1852
leucocyte1870
phagocyte1884
macrophage1887
microphage1887
lymphocyte1890
megakaryocyte1890
hyaline cell1894
macrophagocyte1896
microphagocyte1896
scavenger-cell1899
splenocyte1900
polymorph1902
granulocyte1906
lymphoblast1909
agranulocyte1913
monocyte1913
stab1929
hyaline leucocyte1931
smudge cell1937
heterophile1938
siderophage1941
1906 G. A. Buckmaster Morphol. Normal & Path. Blood iv. 87 According to Pappenheim, all the members of the three groups of erythroblasts, lymphocytes, and granulocytes originate from an ancestral lymphocyte.
1951 L. E. H. Whitby & M. Hynes Med. Bacteriol. (ed. 5) v. 61 The body falls a ready prey to infections of all sorts when the bone-marrow for any reason fails to produce granulocytes.
1960 McGraw-Hill Encycl. Sci. & Technol. VII. 485/2 Of the three kinds of white cells found in normal blood, the granulocytes, the lymphocytes, and the monocytes, it is the granulocytes that are largely affected in most forms of leukopenia.
1968 R. Passmore & J. S. Robson Compan. Med. Stud. I. xxvi. 12/1 The time taken for maturation of a granulocyte in the bone marrow prior to its release into the circulation is believed to be of the order of 3–4 days.
1971 T. L. Lentz Cell Fine Struct. 282 (heading) Endometrial granulocyte.
1971 T. L. Lentz Cell Fine Struct. 282 The granulocyte has been implicated in the secretion of the peptide hormone relaxin.
Derivatives
granuloˈcytic adj.
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1908 Practitioner Feb. 244 A form of lymphatic (i.e., non-granulocytic) leucocythaemia occurs, in which the parent cells have given rise to an excessive formation of Türk's ‘stimulation’ cells.
1962 Lancet 27 Jan. 209/1 We thus came to the tentative conclusion that in the marrow of our standard guineapig..the small lymphocyte functioned as a stem cell for both the red cell and the granulocytic series.
Draft additions June 2003
granulocyte colony-stimulating factor n. Physiology and Medicine any of a group of cytokines that stimulate the proliferation, differentiation, and function of granulocytes, esp. polymorphonuclear leukocytes (neutrophils).
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1971 R. K. Shadduck et al. in Jrnl. Lab. & Clin. Med. 78 53 Injection of mice with pertussis vaccine engendered high levels of granulocyte colony-stimulating factor.
1986 Jrnl. Biol. Chem. 261 12384 Granulocyte colony-stimulating factor (G-CSF) and multipotential colony-stimulating factor (multi-CSF or interleukin 3) are two members of a family of hemopoietic growth and differentiation factors.
1991 Sci. Amer. Feb. 110/2 Amgen will begin selling G-CSF (granulocyte colony-stimulating factor), tradenamed Neupogen, to treat the most common and dangerous side effects of chemotherapy.
1999 Asian-Pacific Jrnl. Allergy & Immunol. 17 289 Granulocyte colony stimulating factors (G-CSFs) play a very important role in the current technique of stem cell transplantation.
This entry has not yet been fully updated (first published 1972; most recently modified version published online June 2018).
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