holocainen.
/ˈhɒləʊkeɪn/ Pharmacology.
The proprietary name of a synthetic derivative, C18H22N2O2, of p-phenetidine which resembles cocaine in its action and is used (in the form of the hydrochloride) as a surface anaesthetic for the eye; phenacaine.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > anaesthetic > [noun] > local > for the eye
holocaine1897
phenacaine1907
amethocaine1941
1897 Lancet 29 May 1466/1 A new alkaloid called holocaine..described as an effective anæsthetic for ophthalmic purposes.
1899 Amer. Jrnl. Med. Sci. 117 121 The bactericidal power of holocain gives it the advantage that solutions..will keep themselves sterile.
1910 L. W. Fox Pract. Treat. Ophthalm. x. 287 The pain caused by this injection is very severe, and to mitigate this the eye should be thoroughly anaesthetized with holocain, cocain being insufficient.
1955 J. Adriani Selection of Anesthesia x. 98 Holocaine is prepared from para-ethoxy aniline (phenetidin).
1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 62 Phenacaine (holocaine) is prompt in action and is used especially for the eye.
This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2021).
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