idiotypen.

Brit.

/ˈɪdɪə(ʊ)ˌtʌɪp/, U.S.

/ˈɪdiəˌtaɪp/

Origin: Formed within English, by derivation. Etymons: idio- comb. form, -type suffix.

Etymology: < idio- comb. form + -type suffix. Compare idiotypic adj. In sense 2 after German Idiotypus (1917 in H. W. Siemens Biol. Grundlagen der Rassenhygiene 31, the source translated in quot. 1924¹); compare idioplasm n. at idio- comb. form . In sense 3b after idiotypic adj. (see sense 3 at that entry, and compare slightly later allotypic adj. 3).

†1. Chemistry. Each of a set of compounds related to one another by substitution of a constituent atom or group. Obsolete. rare.

ΘΚΠ

the world > matter > chemistry > chemical reactions or processes > [noun] > chemical reactions or processes (named) > substitution > derived from the same compound by substitution

idiotype1861

1861 F. Guthrie in Q. Jrnl. Chem. Soc. 13 35 The terms isotype and idiotype, isotypic and idiotypic may be advantageously adopted to denote bodies which belong to similar types, or to the same one, and the relations which such bodies bear to one another... A body is idiotypic with all its replacement derivatives; the latter are, of course, idiotypic with one another; the whole are idiotypes.

2. Genetics. The set of hereditary determinants which characterize an individual; = genotype n.² Now chiefly historical.

ΘΚΠ

the world > life > biology > biological processes > genetic activity > genetic constitution > [noun] > idiotype

idiotype1924

1924 L. F. Barker tr. Siemens' Race Hygiene & Heredity v. 57 This ‘constitutional formula’, the sum of the inheritance rudiments that make up the peculiar innermost nature of the individual we name his inheritance pattern (idiotype or genotype).

1924 Sci. Monthly June 585 The realized adult person is the resultant of a long series of interactions between the zygote (the fertilized ovum, genotype, idiotype) and its environment.

1967 Biologisches Zentralblatt 86 596 The phenotype is the result of an interaction of the idiotype with the environment.

1987 Englera No. 7. 150 Chamisso comes close to the idea that a clone corresponds to one and the same idiotype (genotype).

3. Immunology.

a. A set or class of epitopes characteristic of an individual animal. Cf. idiotope n. 1. rare. Now disused.

ΚΠ

1960 N. K. Jerne in Ann. Rev. Microbiol. 14 342 Epitopes that are carried by components of one individual animal are idiotopes. The idiotypes to which they belong constitute the idiom of the animal.

1971 W. J. Halliday Gloss. Immunol. Terms 25 Idiotype, (1) a class or family of related epitopes; an epitype characteristic of an individual animal.

b. A set of antigenic determinants (idiotopes) characteristic of the variable region of an immunoglobulin (antibody) molecule. Cf. allotype n. 2.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > idiotope

idiotype1967

idiotope1973

1967 Progress in Allergy 11 178 These specificities characteristic of antibodies and presumably determined or co-determined with the antibody combining site itself, have been called..‘idiotypes’.

1972 Jrnl. Immunol. 109 176/1 There is a family of BALB/c plasmacytoma proteins which share an idiotype, bind phosphorylcholine with indistinguishable affinities and are very similar in their primary structure.

1989 Stars & Stripes 5 Dec. 16/2 When a B cell becomes cancerous, the only way to tell it from normal B cells is by the antibody it carries on its surface—its so-called idiotype.

1999 Sunday Tel. (Sydney) (Nexis) 14 Nov. 61 The ‘idiotype’ vaccine uses DNA extracted from a patient's original tumour and is linked with harmless fragments of tetanus toxin.

This entry has been updated (OED Third Edition, November 2010; most recently modified version published online March 2022).

单词	idiotype
释义	idiotypen. Brit. /ˈɪdɪə(ʊ)ˌtʌɪp/, U.S. /ˈɪdiəˌtaɪp/ Origin: Formed within English, by derivation. Etymons: idio- comb. form, -type suffix. Etymology: < idio- comb. form + -type suffix. Compare idiotypic adj. In sense 2 after German Idiotypus (1917 in H. W. Siemens Biol. Grundlagen der Rassenhygiene 31, the source translated in quot. 1924¹); compare idioplasm n. at idio- comb. form . In sense 3b after idiotypic adj. (see sense 3 at that entry, and compare slightly later allotypic adj. 3). †1. Chemistry. Each of a set of compounds related to one another by substitution of a constituent atom or group. Obsolete. rare. ΘΚΠ the world > matter > chemistry > chemical reactions or processes > [noun] > chemical reactions or processes (named) > substitution > derived from the same compound by substitution idiotype1861 1861 F. Guthrie in Q. Jrnl. Chem. Soc. 13 35 The terms isotype and idiotype, isotypic and idiotypic may be advantageously adopted to denote bodies which belong to similar types, or to the same one, and the relations which such bodies bear to one another... A body is idiotypic with all its replacement derivatives; the latter are, of course, idiotypic with one another; the whole are idiotypes. 2. Genetics. The set of hereditary determinants which characterize an individual; = genotype n.² Now chiefly historical. ΘΚΠ the world > life > biology > biological processes > genetic activity > genetic constitution > [noun] > idiotype idiotype1924 1924 L. F. Barker tr. Siemens' Race Hygiene & Heredity v. 57 This ‘constitutional formula’, the sum of the inheritance rudiments that make up the peculiar innermost nature of the individual we name his inheritance pattern (idiotype or genotype). 1924 Sci. Monthly June 585 The realized adult person is the resultant of a long series of interactions between the zygote (the fertilized ovum, genotype, idiotype) and its environment. 1967 Biologisches Zentralblatt 86 596 The phenotype is the result of an interaction of the idiotype with the environment. 1987 Englera No. 7. 150 Chamisso comes close to the idea that a clone corresponds to one and the same idiotype (genotype). 3. Immunology. a. A set or class of epitopes characteristic of an individual animal. Cf. idiotope n. 1. rare. Now disused. ΚΠ 1960 N. K. Jerne in Ann. Rev. Microbiol. 14 342 Epitopes that are carried by components of one individual animal are idiotopes. The idiotypes to which they belong constitute the idiom of the animal. 1971 W. J. Halliday Gloss. Immunol. Terms 25 Idiotype, (1) a class or family of related epitopes; an epitype characteristic of an individual animal. b. A set of antigenic determinants (idiotopes) characteristic of the variable region of an immunoglobulin (antibody) molecule. Cf. allotype n. 2. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > idiotope idiotype1967 idiotope1973 1967 Progress in Allergy 11 178 These specificities characteristic of antibodies and presumably determined or co-determined with the antibody combining site itself, have been called..‘idiotypes’. 1972 Jrnl. Immunol. 109 176/1 There is a family of BALB/c plasmacytoma proteins which share an idiotype, bind phosphorylcholine with indistinguishable affinities and are very similar in their primary structure. 1989 Stars & Stripes 5 Dec. 16/2 When a B cell becomes cancerous, the only way to tell it from normal B cells is by the antibody it carries on its surface—its so-called idiotype. 1999 Sunday Tel. (Sydney) (Nexis) 14 Nov. 61 The ‘idiotype’ vaccine uses DNA extracted from a patient's original tumour and is linked with harmless fragments of tetanus toxin. This entry has been updated (OED Third Edition, November 2010; most recently modified version published online March 2022). < n.1861
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