idiotypicadj.
/ˌɪdɪə(ʊ)ˈtɪpɪk/, U.S. /ˌɪdiəˈtɪpɪk/ΘΚΠ
the world > matter > chemistry > chemical reactions or processes > [adjective] > of or relating to named chemical reactions or processes > of or relating to substitution > derived from the same compound by
substituted1857
idiotypic1861
1861 F. Guthrie in Q. Jrnl. Chem. Soc. 13 35 The terms isotype and idiotype, isotypic and idiotypic may be advantageously adopted to denote bodies which belong to similar types, or to the same one, and the relations which such bodies bear to one another... A body is idiotypic with all its replacement derivatives; the latter are, of course, idiotypic with one another; the whole are idiotypes.
2. Genetics. Of or relating to an individual's idiotype (idiotype n. 2); genetic, inherited. Now rare.
ΘΚΠ
the world > life > biology > biological processes > genetic activity > genetic constitution > [adjective] > of or relating to an idiotype
idiotypic1924
1924 L. F. Barker tr. Siemens' Race Hygiene & Heredity v. 58 It was the study of the offspring of each individual red F2-plant that taught us to recognize what inheritance factors (idiotypic rudiments) lay concealed within the mother plant.
1961 L. F. Brosnahan Sounds of Lang. vi. 147 Each child has its own proper inheritance which is revealed in his idiotypic capacity in speech development.
1963 F. Lenz in S. H. Boyer Papers Human Genetics 24 Like deafmutism, dementia praecox is not an idiotypic entity.
3. Immunology. Of or relating to the idiotype of an immunoglobulin molecule (idiotype n. 3); (of a vaccine) directed against an idiotype.
ΘΚΠ
the world > life > biology > substance > process stimulators or inhibitors > antibody > [adjective] > of or belonging to an idiotype
idiotypic1966
1966 J. Oudin in Jrnl. Cellular Physiol. 67 Suppl. 94/1 These antigenic specificities vary with individuals... Since each of them seems to be peculiar to antibodies against one antigen in an individual or a restricted class of individuals, they seem to deserve the name of idiotypic specificity, which indicates this notion of peculiarity.
1988 Nature 20 Oct. 730/2 The T3.70 antibody is specific for an idiotypic determinant dependent on the expression of both α and β transgenic TCR [= T-cell receptor] chains.
2000 C. A. Bona & A. I. Bot Genetic Immunization viii. 112 The design of idiotypic vaccines would require..the isolation of tumor-associated Fv segments from patients that can be assembled into expression vectors.
Derivatives
ˌidioˈtypically adv. as regards idiotypes; by means of idiotypes.
ΘΚΠ
the world > life > biology > biological processes > genetic activity > genetic constitution > [adverb] > of an idiotype
idiotypically1924
1924 L. F. Barker tr. Siemens' Race Hygiene & Heredity v. 61 Among human beings, who are heterozygous with respect to many pairs of inheritance factors, idiotypically identical persons occur only..when two children arise from a single fertilized egg cell.
1974 Nature 4 Jan. 56/2 The study of the response to phosphorylcholine in mice which have been idiotypically suppressed at different stages of ontogeny may indicate the origin of this clonal restriction.
2007 Immunobiology 212 58/2 An antibody resulting from a mature response is less idiotypically connected than a germline antibody.
This entry has been updated (OED Third Edition, November 2010; most recently modified version published online March 2022).
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