hypermutabilityn.
/ˌhʌɪpəmjuːtəˈbɪlᵻti/, U.S. /ˈˌhaɪpərˌmjudəˈbɪlᵻdi/ Genetics.
The state or condition of undergoing mutation at a high rate, or of being highly prone to mutation.
ΚΠ
1959 Science 19 June 1650/1 The genic diversity..arises from a high rate of spontaneous mutation... This hypermutability consists of the random assembly of the DNA of the globulin gene during certain stages of cellular proliferation.
1975 Proc. National Acad. Sci. U.S.A. 72 819/1 The hypervariable regions provide the molecule with a combining surface which, because of the hypermutability of its constituents, can account for the diversity of the antibody response as well as its specificity.
1990 Independent (Nexis) 5 Nov. 15 Only the idea of hypermutability breaks new ground and suggests that ‘directed’ mutation really exists; the other two ideas depend on random variation and then the exercise of natural selection.
2003 Nature Genetics 34 326 Chronic exposure of yeast to environmentally relevant concentrations of cadmium, a known human carcinogen, can result in extreme hypermutability.
This is a new entry (OED Third Edition, December 2004; most recently modified version published online March 2022).
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