hypermutableadj.

Brit.

/ˌhʌɪpəˈmjuːtəbl/, U.S.

/ˌhaɪpərˈmjudəb(ə)l/

Origin: Formed within English, by derivation. Etymons: hyper- prefix, mutable adj.

Etymology: < hyper- prefix + mutable adj. Compare slightly earlier hypermutability n.

Genetics.

Undergoing or characterized by frequent mutation; highly prone to mutation; highly susceptible to mutagenesis.

ΚΠ

1960 New Biol. 31 105 Its main assumptions, however—e.g. that individual mesenchymal cells are..hypermutable, and that they are stimulated to proliferate and produce antibody by contact with antigen—are far from proved.

1978 Molecular & Gen. Genetics 163 307 [These] mutants however were not found to be hypermutable by UV light.

1989 A. J. Jefferys in J. R. Durant Human Origins iii. 43 These convergences may be due to specific nucleotide sites which are hypermutable for some biochemical reason.

2001 Cytogenetics & Cell Genetics 92 177 A second pathway toward malignancy has emerged..characterized..by inactivation of the DNA mismatch repair system, leading to a hypermutable state in which simple repetitive DNA sequences are unstable during DNA replication.

This is a new entry (OED Third Edition, December 2004; most recently modified version published online March 2022).

单词	hypermutable
释义	hypermutableadj. Brit. /ˌhʌɪpəˈmjuːtəbl/, U.S. /ˌhaɪpərˈmjudəb(ə)l/ Origin: Formed within English, by derivation. Etymons: hyper- prefix, mutable adj. Etymology: < hyper- prefix + mutable adj. Compare slightly earlier hypermutability n. Genetics. Undergoing or characterized by frequent mutation; highly prone to mutation; highly susceptible to mutagenesis. ΚΠ 1960 New Biol. 31 105 Its main assumptions, however—e.g. that individual mesenchymal cells are..hypermutable, and that they are stimulated to proliferate and produce antibody by contact with antigen—are far from proved. 1978 Molecular & Gen. Genetics 163 307 [These] mutants however were not found to be hypermutable by UV light. 1989 A. J. Jefferys in J. R. Durant Human Origins iii. 43 These convergences may be due to specific nucleotide sites which are hypermutable for some biochemical reason. 2001 Cytogenetics & Cell Genetics 92 177 A second pathway toward malignancy has emerged..characterized..by inactivation of the DNA mismatch repair system, leading to a hypermutable state in which simple repetitive DNA sequences are unstable during DNA replication. This is a new entry (OED Third Edition, December 2004; most recently modified version published online March 2022). < adj.1960
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