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hypersplenism
hypersplenism n. 
/ˌhʌɪpəˈsplɛnɪz(ə)m/, /ˌhaɪpərˈsplɛˌnɪzəm/ [splen- comb. form] Pathology over-activity of the spleen; spec. a condition characterized by a general destruction of blood cells, often associated with enlargement of the spleen but in which direct involvement of the spleen is now considered doubtful.
Brit. /ˌhʌɪpəˈspliːnɪz(ə)m/
, /ˌhʌɪpəˈspliːnɪz(ə)m//ˌhʌɪpəˈsplɛnɪz(ə)m/U.S. /ˌhaɪpərˈspliˌnɪzəm/
, /ˌhaɪpərˈspliˌnɪzəm//ˌhaɪpərˈsplɛˌnɪzəm/ΘΚΠ
the world > health and disease > ill health > a disease > disorders of internal organs > glandular disorders > [noun] > disorders of spleen
elf-cake1579
ague cake1597
splenitis1753
lienitis1845
perisplenitis1881
wandering spleen1897
splenohepatomegaly1900
spleno-megaly1900
hypersplenism1914
hyposplenism1914
splenosis1939
1914 Arch. Internal Med. 14 145 There may exist for the spleen conditions associated with a hyperactivity of some of its functions, let us say the function of influencing hemolysis. To such a condition the term ‘hypersplenism’ may be applied.
1955 W. Dameshek in Bull. N.Y. Acad. Med. 31 114 Who first used the term ‘hypersplenism’ is not accurately known, but it began to appear in Chauffard's writings from 1907 on and subsequently, and in those of Morawitz and Eppinger at a late date.
1963 A. K. Basu & B. K. Aikat Trop. Splenomegaly iii. 20 Hypersplenism..is a clinical term indicating non-specific overactive function of the spleen in a variety of clinical disorders.
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