imipraminen.

/ɪˈmɪprəmiːn/

Etymology: Rearrangement of some elements of dimethyl-amino propyl- iminodibenzyl , a systematic name for this compound: see -ine suffix⁵.

Pharmacology.

A tricyclic tertiary amine, C₁₉H₂₄N₂, given orally as the hydrochloride, a white crystalline compound, in the treatment of endogenous depression.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs

Marsilid1952

iproniazid1953

levallorphan1953

imipramine1958

Tofranil1958

isocarboxazid1959

Marplan1959

Nardil1959

nialamide1959

Niamid1959

phenelzine1959

tranylcypromine1959

Parnate1960

amitriptyline1961

monoamine oxidase inhibitor1962

nortriptyline1962

protriptyline1963

MAOI1965

maprotiline1970

mianserin1970

amoxapine1971

fluoxetine1975

paroxetine1977

Prozac1985

Seroxat1985

1958 Amer. Jrnl. Psychiatry 115 459 (heading) The treatment of depressive states with G 22355 (imipramine hydrochloride).

1960 Brit. Med. Jrnl. 30 Jan. 348/2 We have..noted the development of jaundice and also hypomania in patients receiving therapeutic doses of imipramine.

1963 Lancet 23 Mar. 638/2 The administration to pregnant rabbits of imipramine (‘Tofranil’) led to the development of fœtal abnormalities.

1964 Hafliger & Burckhardt in M. Gordon Psychopharmacol. Agents I. iii. 77 Imipramine has no influence upon monoamine oxidase.

1964 Hafliger & Burckhardt in M. Gordon Psychopharmacol. Agents I. iii. 89 The most frequent side effecs of imipramine..include dryness of the mouth, sweating, disturbance of accommodation, constipation, insomnia, and giddiness.

1965 Nursing Times 5 Feb. 187/1 Either electro-convulsive therapy or one of the antidepressant drugs (such as imipramine—Tofranil) will probably be used.

1965 J. Pollitt Depression & its Treatm. iv. 58 Imipramine is effective mainly in Type S classical (retarded) depressions, and in depressed patients of middle age and over. It is less valuable in atypical depression, and in sensitive or hysterical personalities the ordinary mild side effects may cause bitter complaint.

1972 Brit. Med. Jrnl. 1 Apr. 45/2 These fairly substantial figures do not support the view that imipramine is liable to cause fetal abnormalities if given to pregnant women.

This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2018).

单词	imipramine
释义	imipraminen. /ɪˈmɪprəmiːn/ Etymology: Rearrangement of some elements of dimethyl-amino propyl- iminodibenzyl , a systematic name for this compound: see -ine suffix⁵. Pharmacology. A tricyclic tertiary amine, C₁₉H₂₄N₂, given orally as the hydrochloride, a white crystalline compound, in the treatment of endogenous depression. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs Marsilid1952 iproniazid1953 levallorphan1953 imipramine1958 Tofranil1958 isocarboxazid1959 Marplan1959 Nardil1959 nialamide1959 Niamid1959 phenelzine1959 tranylcypromine1959 Parnate1960 amitriptyline1961 monoamine oxidase inhibitor1962 nortriptyline1962 protriptyline1963 MAOI1965 maprotiline1970 mianserin1970 amoxapine1971 fluoxetine1975 paroxetine1977 Prozac1985 Seroxat1985 1958 Amer. Jrnl. Psychiatry 115 459 (heading) The treatment of depressive states with G 22355 (imipramine hydrochloride). 1960 Brit. Med. Jrnl. 30 Jan. 348/2 We have..noted the development of jaundice and also hypomania in patients receiving therapeutic doses of imipramine. 1963 Lancet 23 Mar. 638/2 The administration to pregnant rabbits of imipramine (‘Tofranil’) led to the development of fœtal abnormalities. 1964 Hafliger & Burckhardt in M. Gordon Psychopharmacol. Agents I. iii. 77 Imipramine has no influence upon monoamine oxidase. 1964 Hafliger & Burckhardt in M. Gordon Psychopharmacol. Agents I. iii. 89 The most frequent side effecs of imipramine..include dryness of the mouth, sweating, disturbance of accommodation, constipation, insomnia, and giddiness. 1965 Nursing Times 5 Feb. 187/1 Either electro-convulsive therapy or one of the antidepressant drugs (such as imipramine—Tofranil) will probably be used. 1965 J. Pollitt Depression & its Treatm. iv. 58 Imipramine is effective mainly in Type S classical (retarded) depressions, and in depressed patients of middle age and over. It is less valuable in atypical depression, and in sensitive or hysterical personalities the ordinary mild side effects may cause bitter complaint. 1972 Brit. Med. Jrnl. 1 Apr. 45/2 These fairly substantial figures do not support the view that imipramine is liable to cause fetal abnormalities if given to pregnant women. This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2018). < n.1958
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