indomethacinn.

/ɪndəʊˈmɛθəsɪn/

Etymology: < indo- (in indole n.) meth- (in methyl n.) + ac- (in acetic adj.) (words which occur in the systematic name: see quot. 1963¹) + -in suffix¹.

Pharmacology.

A yellowish-white powdery indole derivative, C₁₉H₁₆NO₄Cl, which has anti-inflammatory, anti-pyretic, and analgesic properties and has been given orally in the treatment of rheumatoid arthritis, gout, and similar conditions.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for arthritis, rheumatism, or gout > others

Portland powder1763

helmitol1903

probenecid1950

indomethacin1963

allopurinol1964

ibuprofen1967

naproxen1971

sulindac1975

1963 T. Y. Shen et al. in Jrnl. Amer. Chem. Soc. LXXXV. 488/2 We wish to report a new class of anti-inflammatory and antipyretic agents, substituted indole acetic and propionic acids... One member of the series, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid.., designated as indomethacin, has demonstrated a high degree of anti-inflammatory activity.

1963 New Scientist 10 Oct. 103/2 One patient, aged 73, had had arthritis for 30 years and was bed-ridden with inflamed joints and a temperature. Within three days of being given indomethacin the temperature fell to normal and pain was relieved.

1968 Clin. Pharmacol. & Therapeutics IX. 94 Indomethacin may be useful in treating other..rheumatic diseases, but as yet few comparisons with other standard therapies have been made. The drug has severe side effects and should be used with caution.

1971 New Scientist 24 June 745/2 This..might well eliminate the gastrointestinal side-effects of drugs such as indomethacin used to treat rheumatoid diseases.

This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2018).

单词	indomethacin
释义	indomethacinn. /ɪndəʊˈmɛθəsɪn/ Etymology: < indo- (in indole n.) meth- (in methyl n.) + ac- (in acetic adj.) (words which occur in the systematic name: see quot. 1963¹) + -in suffix¹. Pharmacology. A yellowish-white powdery indole derivative, C₁₉H₁₆NO₄Cl, which has anti-inflammatory, anti-pyretic, and analgesic properties and has been given orally in the treatment of rheumatoid arthritis, gout, and similar conditions. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for arthritis, rheumatism, or gout > others Portland powder1763 helmitol1903 probenecid1950 indomethacin1963 allopurinol1964 ibuprofen1967 naproxen1971 sulindac1975 1963 T. Y. Shen et al. in Jrnl. Amer. Chem. Soc. LXXXV. 488/2 We wish to report a new class of anti-inflammatory and antipyretic agents, substituted indole acetic and propionic acids... One member of the series, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid.., designated as indomethacin, has demonstrated a high degree of anti-inflammatory activity. 1963 New Scientist 10 Oct. 103/2 One patient, aged 73, had had arthritis for 30 years and was bed-ridden with inflamed joints and a temperature. Within three days of being given indomethacin the temperature fell to normal and pain was relieved. 1968 Clin. Pharmacol. & Therapeutics IX. 94 Indomethacin may be useful in treating other..rheumatic diseases, but as yet few comparisons with other standard therapies have been made. The drug has severe side effects and should be used with caution. 1971 New Scientist 24 June 745/2 This..might well eliminate the gastrointestinal side-effects of drugs such as indomethacin used to treat rheumatoid diseases. This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2018). < n.1963
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