intronn.

1978 W. Gilbert in Nature 9 Feb. 501/1 The notion of the cistron..must be replaced by that of a transcription unit containing regions which will be lost from the mature messenger—which I suggest we call introns (for intragenic regions)—alternating with regions which will be expressed— exons.

1980 Sci. Amer. Sept. 87/3 A similar explanation could account for introns, the noncoding sequences that interrupt coding sequences in many eukaryotic genes.

1980 Amer. Jrnl. Trop. Med. & Hygiene 29 1034/1 These results show that VSG genes are not riddled with introns.

1981 Sci. Amer. May 55/1 Protein-coding exonic sequences evolve slowly, mainly by point mutations in which one base replaces another, whereas such noncoding sequences as introns evolve much faster by insertion and deletion events of variable extent.

1982 P. N. Gray in T. M. Devlin Textbk. Biochem. xviii. 910 The nucleotide sequences of the intron–exon borders have some similarities that appear to be common for several species. Introns in RNA generally begin with..pGpU..and end with..pApG.

1985 B. Lewin Genes (ed. 2) xx. 362 Many of the long introns in these genes have open reading frames in register with the preceding exon; at least in some cases, there is evidence for translation of the intron.

1978 Nature 9 Feb. 501/1 The gene is a mosaic: expressed sequences held in a matrix of silent DNA, an intronic matrix.

1980 Ann. N.Y. Acad. Sci. 343 430 The middle of the hybridized strand..was looped out, presumably because the intronic sequence was spliced out from the mRNA.

1985 Science 20 Sept. 1264/3 The abundance of this repeat in nuclear RNA of the rat and mouse is roughly proportional to the copy number of the sequence in the respective genomes. This is consistent with the notion of random intronic distribution and transcription of this repeat.