isocarboxazidn.
/ˌʌɪsəʊkɑːˈbɒksəzɪd/ Pharmacology.
A whitish powder that is a hydrazine derivative, C6H5CH2NH·NHCO·C3HNO·CH3, and is used as an antidepressant.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs
Marsilid1952
iproniazid1953
levallorphan1953
imipramine1958
Tofranil1958
isocarboxazid1959
Marplan1959
Nardil1959
nialamide1959
Niamid1959
phenelzine1959
tranylcypromine1959
Parnate1960
amitriptyline1961
monoamine oxidase inhibitor1962
nortriptyline1962
protriptyline1963
MAOI1965
maprotiline1970
mianserin1970
amoxapine1971
fluoxetine1975
paroxetine1977
Prozac1985
Seroxat1985
1959 Diseases Nervous Syst. XX. 269/1 An analog of iproniazid, isocarboxazid.., has been used in pharmacological studies which show it to be a more potent amine oxidase inhibitor than its progenitor. Its chemical formula is 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)-hydrazine.
1963 Jrnl. Amer. Med. Assoc. 16 Mar. 952/1 It is the opinion of the Council that isocarboxazid seems to be effective in the depressed phases of anxiety and manic-depressive states as well as in certain involutional, obsessive, and disassociative reactions.
1965 J. Pollitt Depression & its Treatm. iv. 56 The monoamine oxidase inhibitors include several members, among them phenelzine (Nardil), iproniazid (Marsilid), isocarboxazid (Marplan).
This entry has not yet been fully updated (first published 1976; most recently modified version published online June 2018).
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n.1959