isophaneisophenen.

/ˈʌɪsə(ʊ)feɪn/

/ˈaɪsə(ʊ)fiːn/

Etymology: formed as isophane adj.; compare phen- comb. form, pheno- comb. form.

A line (imaginary or on a map) linking places in which seasonal biological phenomena (the flowering of plants, etc.) occur at the same time.

ΘΚΠ

the world > the earth > earth sciences > geography > map-making > map > [noun] > line on map > biological phenomena

isophane1918

isepiptesis1926

isochar1963

1918 A. D. Hopkins in Monthly Weather Rev. (U.S.) Suppl. No. 9. 9/1 Taking base maps of North America and of the major and minor political divisions, parallel lines (designated as isophanes) are drawn on them to define, according to the bioclimatic law, theoretical lines and zones of equal phenomena as to time of occurrence and equal bioclimatic conditions, at the same level.

1929 V. E. Shelford Lab. & Field Ecol. i. 15 An isophenal map was prepared with isophenes drawn through equal-event dates at the same altitude.

1931 Trans. Entomol. Soc. Lond. 79 183 Local conditions..cause considerable departures in the actual dates of seasonal events from those indicated by isophanes.

1947 R. F. Daubenmire Plants & Environment iv. 219 From phenologic data maps can be drawn with lines (isophenes) connecting locations where plants are in the same stage of development at the same time.

1963 E. Mayr Animal Species & Evol. xiii. 362 This north-south cline is crossed by the isophenes, lines connecting all populations with the same phenotype.

Derivatives

isoˈphanal adj.

ΚΠ

1931 Trans. Entomol. Soc. Lond. 79 183 Instead of basing the isophanal map on degrees of latitude and longitude, he [sc. Znamenskiǐ] made use of the mean annual isotherms.

isoˈphenal adj.

ΘΚΠ

the world > the earth > earth sciences > geography > map-making > map > [adjective] > line on map > biological phenomena

isophenal1918

1918 A. D. Hopkins in Monthly Weather Rev. (U.S.) Suppl. No. 9. 8 (caption) Isophenal map of North America.

This entry has not yet been fully updated (first published 1976; most recently modified version published online March 2020).

isophaneadj.

/ˈʌɪsəʊfeɪn/

Etymology: < iso- comb. form + Greek -ϕανης showing, appearing ( < ϕαίνειν to show, cause to appear).

Pharmacology.

a. Designating that ratio of protamine to insulin which, in a solution made by mixing solutions of the individual substances, gives rise to equal turbidity in two equal samples taken after a precipitate has been allowed to form when one sample has sufficient insulin added to it to precipitate all the protamine in it and the other a sufficient amount of protamine to precipitate all the insulin.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [adjective] > ratio of protamine to insulin

isophane1946

1946 Krayenbühl & Rosenberg in Rep. Steno Memorial Hosp. I. 65 The proportion of protamine to insulin must be nearly isophane. At isophane proportions the formation of crystals is rapid.

1950 Federal Register (U.S.) 2 Nov. 7363/2 The isophane ratio shall be expressed as milligrams of protamine per 100 U.S.P. Units of insulin.

1955 Dispensatory U.S.A. (ed. 25) 686/2 The most useful of these mixtures, for many patients, proved to be the 2:1 mixture of regular insulin and protamine zinc insulin. In this mixture protamine is present to the extent of about 0·5 mg. per 100 units of insulin, which is the combining proportion, or so-called isophane ratio, of protamine and insulin.

b. Applied to a crystalline mixture of insulin and protamine in the isophane ratio with zinc, which has longer-lasting effects than pure insulin. Also elliptical as n.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [noun]

epinephrine1899

pituitrin1909

oxytocin1927

Pitocin1929

Pitressin1929

progestin1930

progesterone1935

methyltestosterone1936

pregnenolone1936

hexœstrol1939

stilboestrol1939

hydroxyprogesterone1941

progestogen1941

Premarin1942

hydroxycorticosterone1943

gestagen1948

hydrocortisone1951

cortisol1953

fluorohydrocortisone1954

isophane1954

prednisolone1955

prednisone1955

norethisterone1956

norethynodrel1957

dexamethasone1958

fludrocortisone1958

norethindrone1960

antidiuretic hormone1961

medroxyprogesterone1962

Pergonal1963

mesterolone1965

norgestrel1966

quinestrol1966

pancuronium1967

pentagastrin1967

levonorgestrel1977

1954 A. Grollman Pharmacol. & Therapeutics (ed. 2) xxvi. 606 (table) NPH Insulin (Isophane).

1955 Dispensatory U.S.A. (ed. 25) 686/2 In preparing Isophane Insulin Injection, sufficient insulin is used to provide either 40 or 80 U.S.P. Insulin Units for each ml. of the Injection.

1955 Brit. Med. Jrnl. 19 Feb. 478/2 Having used isophane..since November, 1953, and in more than 60 diabetics, I find it easily the most satisfactory one-shot-a-day insulin available.

1966 Lancet 24 Dec. 1389/2 A 20-year-old diabetic patient, who was poorly controlled on 45 units isophane insulin in the morning and 35 units isophane insulin in the evening, was admitted in diabetic ketoacidosis.

1968 Pond & Oakley in W. G. Oakley et al. Clin. Diabetes xxiii. 602 A comparable method of control by a single morning injection is the use of a mixture of isophane (NPH) and SI.

This entry has not yet been fully updated (first published 1976; most recently modified version published online March 2019).

单词	isophane
释义	isophaneisophenen. /ˈʌɪsə(ʊ)feɪn/ /ˈaɪsə(ʊ)fiːn/ Etymology: formed as isophane adj.; compare phen- comb. form, pheno- comb. form. A line (imaginary or on a map) linking places in which seasonal biological phenomena (the flowering of plants, etc.) occur at the same time. ΘΚΠ the world > the earth > earth sciences > geography > map-making > map > [noun] > line on map > biological phenomena isophane1918 isepiptesis1926 isochar1963 1918 A. D. Hopkins in Monthly Weather Rev. (U.S.) Suppl. No. 9. 9/1 Taking base maps of North America and of the major and minor political divisions, parallel lines (designated as isophanes) are drawn on them to define, according to the bioclimatic law, theoretical lines and zones of equal phenomena as to time of occurrence and equal bioclimatic conditions, at the same level. 1929 V. E. Shelford Lab. & Field Ecol. i. 15 An isophenal map was prepared with isophenes drawn through equal-event dates at the same altitude. 1931 Trans. Entomol. Soc. Lond. 79 183 Local conditions..cause considerable departures in the actual dates of seasonal events from those indicated by isophanes. 1947 R. F. Daubenmire Plants & Environment iv. 219 From phenologic data maps can be drawn with lines (isophenes) connecting locations where plants are in the same stage of development at the same time. 1963 E. Mayr Animal Species & Evol. xiii. 362 This north-south cline is crossed by the isophenes, lines connecting all populations with the same phenotype. Derivatives isoˈphanal adj. ΚΠ 1931 Trans. Entomol. Soc. Lond. 79 183 Instead of basing the isophanal map on degrees of latitude and longitude, he [sc. Znamenskiǐ] made use of the mean annual isotherms. isoˈphenal adj. ΘΚΠ the world > the earth > earth sciences > geography > map-making > map > [adjective] > line on map > biological phenomena isophenal1918 1918 A. D. Hopkins in Monthly Weather Rev. (U.S.) Suppl. No. 9. 8 (caption) Isophenal map of North America. This entry has not yet been fully updated (first published 1976; most recently modified version published online March 2020). isophaneadj. /ˈʌɪsəʊfeɪn/ Etymology: < iso- comb. form + Greek -ϕανης showing, appearing ( < ϕαίνειν to show, cause to appear). Pharmacology. a. Designating that ratio of protamine to insulin which, in a solution made by mixing solutions of the individual substances, gives rise to equal turbidity in two equal samples taken after a precipitate has been allowed to form when one sample has sufficient insulin added to it to precipitate all the protamine in it and the other a sufficient amount of protamine to precipitate all the insulin. ΘΚΠ the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [adjective] > ratio of protamine to insulin isophane1946 1946 Krayenbühl & Rosenberg in Rep. Steno Memorial Hosp. I. 65 The proportion of protamine to insulin must be nearly isophane. At isophane proportions the formation of crystals is rapid. 1950 Federal Register (U.S.) 2 Nov. 7363/2 The isophane ratio shall be expressed as milligrams of protamine per 100 U.S.P. Units of insulin. 1955 Dispensatory U.S.A. (ed. 25) 686/2 The most useful of these mixtures, for many patients, proved to be the 2:1 mixture of regular insulin and protamine zinc insulin. In this mixture protamine is present to the extent of about 0·5 mg. per 100 units of insulin, which is the combining proportion, or so-called isophane ratio, of protamine and insulin. b. Applied to a crystalline mixture of insulin and protamine in the isophane ratio with zinc, which has longer-lasting effects than pure insulin. Also elliptical as n. ΘΚΠ the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [noun] epinephrine1899 pituitrin1909 oxytocin1927 Pitocin1929 Pitressin1929 progestin1930 progesterone1935 methyltestosterone1936 pregnenolone1936 hexœstrol1939 stilboestrol1939 hydroxyprogesterone1941 progestogen1941 Premarin1942 hydroxycorticosterone1943 gestagen1948 hydrocortisone1951 cortisol1953 fluorohydrocortisone1954 isophane1954 prednisolone1955 prednisone1955 norethisterone1956 norethynodrel1957 dexamethasone1958 fludrocortisone1958 norethindrone1960 antidiuretic hormone1961 medroxyprogesterone1962 Pergonal1963 mesterolone1965 norgestrel1966 quinestrol1966 pancuronium1967 pentagastrin1967 levonorgestrel1977 1954 A. Grollman Pharmacol. & Therapeutics (ed. 2) xxvi. 606 (table) NPH Insulin (Isophane). 1955 Dispensatory U.S.A. (ed. 25) 686/2 In preparing Isophane Insulin Injection, sufficient insulin is used to provide either 40 or 80 U.S.P. Insulin Units for each ml. of the Injection. 1955 Brit. Med. Jrnl. 19 Feb. 478/2 Having used isophane..since November, 1953, and in more than 60 diabetics, I find it easily the most satisfactory one-shot-a-day insulin available. 1966 Lancet 24 Dec. 1389/2 A 20-year-old diabetic patient, who was poorly controlled on 45 units isophane insulin in the morning and 35 units isophane insulin in the evening, was admitted in diabetic ketoacidosis. 1968 Pond & Oakley in W. G. Oakley et al. Clin. Diabetes xxiii. 602 A comparable method of control by a single morning injection is the use of a mixture of isophane (NPH) and SI. This entry has not yet been fully updated (first published 1976; most recently modified version published online March 2019). < n.1918adj.1946
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