labetaloln.

Brit.

/ləˈbiːtəlɒl/, U.S.

/ləˈbɛdəˌlɔl/,

/ləˈbɛdəˌlɑl/,

/ləˈbɛdəˌloʊl/

Origin: Formed within English, by compounding. Etymons: alpha n., beta n., -olol comb. form.

Etymology: < la- (perhaps an inversion of al- (in alpha n.)) + beta n. + -lol (in -olol comb. form), with reference to the fact that the drug is related to alpha and beta adrenoceptors and propanolol.

Pharmacology.

A drug that acts as an alpha- and beta-blocker, used in the treatment of hypertension.Chemical name: 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide, C₁₉H₂₄N₂O₃. There are four stereoisomers with differing degrees of activity; it is typically given as a mixture.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations for treating specific parts > [noun] > for the heart > specific drugs

khellin1879

procainamide1950

pronethalol1963

propranolol1964

alprenolol1967

verapamil1967

oxprenolol1968

sotalol1968

perhexiline1969

practolol1969

beta-blocker1970

pindolol1971

acebutolol1972

mexiletine1973

atenolol1974

metoprolol1974

labetalol1975

propafenone1975

amrinone1977

1975 Approved Names 1973 (Brit. Pharmacopœia Comm.) Suppl. v. Labetalol.

1977 Lancet 23 Apr. 890/2 If the alpha-blocking potency of labetalol is sufficient to enhance blood-pressure control substantially, it may also be sufficient to cause disabling symptoms.

1987 D. J. Weatherall et al. Oxf. Textbk. Med. (ed. 2) II. xiii. 374/2 Although the α-blocking potency is relatively mild labetalol appears to be significantly better in hypotensive potency than a β-blocker alone.

2013 Brit. Med. Jrnl. 2 Mar. 30/1 Suggested first line antihypertensive drugs that are safe in breastfeeding mothers include labetalol, nifedipine, and enalapril.

This entry has been updated (OED Third Edition, June 2018; most recently modified version published online March 2022).

单词	labetalol
释义	labetaloln. Brit. /ləˈbiːtəlɒl/, U.S. /ləˈbɛdəˌlɔl/, /ləˈbɛdəˌlɑl/, /ləˈbɛdəˌloʊl/ Origin: Formed within English, by compounding. Etymons: alpha n., beta n., -olol comb. form. Etymology: < la- (perhaps an inversion of al- (in alpha n.)) + beta n. + -lol (in -olol comb. form), with reference to the fact that the drug is related to alpha and beta adrenoceptors and propanolol. Pharmacology. A drug that acts as an alpha- and beta-blocker, used in the treatment of hypertension.Chemical name: 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide, C₁₉H₂₄N₂O₃. There are four stereoisomers with differing degrees of activity; it is typically given as a mixture. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations for treating specific parts > [noun] > for the heart > specific drugs khellin1879 procainamide1950 pronethalol1963 propranolol1964 alprenolol1967 verapamil1967 oxprenolol1968 sotalol1968 perhexiline1969 practolol1969 beta-blocker1970 pindolol1971 acebutolol1972 mexiletine1973 atenolol1974 metoprolol1974 labetalol1975 propafenone1975 amrinone1977 1975 Approved Names 1973 (Brit. Pharmacopœia Comm.) Suppl. v. Labetalol. 1977 Lancet 23 Apr. 890/2 If the alpha-blocking potency of labetalol is sufficient to enhance blood-pressure control substantially, it may also be sufficient to cause disabling symptoms. 1987 D. J. Weatherall et al. Oxf. Textbk. Med. (ed. 2) II. xiii. 374/2 Although the α-blocking potency is relatively mild labetalol appears to be significantly better in hypotensive potency than a β-blocker alone. 2013 Brit. Med. Jrnl. 2 Mar. 30/1 Suggested first line antihypertensive drugs that are safe in breastfeeding mothers include labetalol, nifedipine, and enalapril. This entry has been updated (OED Third Edition, June 2018; most recently modified version published online March 2022). < n.1975
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