leukotrienen.
/l(j)uːkəʊˈtrʌɪiːn/ Biochemistry.
Any of a group of biologically active metabolites of arachidonic acid, originally isolated from leucocytes, which contain three conjugated double bonds.
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ectocrine1947
probiotic1959
cytochalasin1966
leukotriene1979
1979 B. Samuelsson et al. in Prostaglandins 17 785 The term leukotriene is introduced for compounds which like SRS [sc. slow reacting substance] are non-cyclized C20 carboxylic acids with one or two oxygen substituents and three conjugated double bonds.
1983 D. J. Weatherall et al. Oxf. Textbk. Med. II. xv. 60 Humoral mediators producing bronchoconstriction..include histamine, the leucotrienes, and bradykinin.
1984 J. R. Tighe & D. R. Davies Pathol. (ed. 4) iii. 15 The leukotrienes..have been shown to be responsible for the activity attributed to slow-reacting substance (SRS) in the earlier literature.
1989 Nature 9 Feb. 555/1 Arachidonic acid is converted to prostaglandins by cyclooxygenase and to leukotrienes by 5-lipoxygenase.
This entry has not yet been fully updated (first published 1997; most recently modified version published online March 2021).
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n.1979