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单词 levallorphan
释义

levallorphann.

/ˌliːvəˈlɔːfan/
Etymology: < lev- (in laevo- comb. form) + all- (in allyl n.) + -orph- (in morphine n.) + -an suffix, elements of the systematic name.
Pharmacology.
A morphine analogue and opioid antagonist, C19H25NO, given intravenously (usually as the tartrate) to counteract some of the depressant effects of certain narcotics.
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Marsilid1952
iproniazid1953
levallorphan1953
imipramine1958
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Marplan1959
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protriptyline1963
MAOI1965
maprotiline1970
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fluoxetine1975
paroxetine1977
Prozac1985
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1953 Anesthesiology 14 550 Levallorphan is the generic name of 3-hydroxy-N-allylmorphan and was originally designated as R0 1-7700.
1977 Drug Metabolism & Disposition V. 273 Narcotic antagonists, naloxone, nalorphine, levallorphan, and naltrexone, specifically inhibited morphine glucuronidation.
1988 Biol. Abstr. 85 xi. ab929/1 Neuroleptanalgesia was performed by intravenous injection of fentanyl and levallorphan 5 minutes before local anesthesia.
1989 Martindale's Extra Pharmacopoeia (ed. 29) 84 2/2 Levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory such as that induced by alcohol or other non-opioid central depressants.
This entry has not yet been fully updated (first published 1997; most recently modified version published online June 2018).
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n.1953
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