单词 | lymphokine |
释义 | > as lemmaslymphokine lymphokine n. Brit. , U.S. [ < Greek κινεῖν to move] Immunology any of various soluble substances released by lymphocytes following activation by contact with an antigen which are thought to be involved in cell-mediated immunity but to lack the antigen-specificity of antibodies.ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > lymphokine lymphokine1969 macrophage activating factor1974 macrophage activation factor1984 1969 D. C. Dumonde et al. in Nature 4 Oct. 38/1 In the guinea-pig these four phenomena are mediated by cell-free soluble factors, which are generated during interaction of sensitized lymphocytes with specific antigen, but which are expressed without reference to immunological specificity. The generic term ‘lymphokine’ is suggested to describe this group of biological activities. 1973 Nature 2 Mar. 22/2 When T cells are activated by antigen, they proliferate..but they..do not become antibody-secreting cells. They do, however, secrete a variety of non-antigen~specific factors (‘lymphokines’) such as migration inhibition factors (MIF), chemotactic factors, cytotoxic factors and mitogenic factors, at least some of which presumably play a role in cell-mediated immune responses, for which T cells are primarily responsible. 1974 Sci. Amer. Apr. 36/2 Transplantation antigens and other foreign material..stimulate the production and release of ‘sensitized’ lymphocytes, or effector cells... In addition to killing graft cells directly the sensitized lymphocytes secrete a variety of chemical agents called lymphokines, some of which act directly on the foreign cells and some of which attract other leukocytes..which digest damaged cells and cell fragments. < as lemmas |
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