macroglobulinn.
/ˌmakrəʊˈɡlɒbjᵿlɪn/, U.S. /ˈˌmækroʊˈɡlɑbjələn/ Biochemistry and Medicine.
Any blood plasma globulin of high molecular weight (usually, greater than 400,000); esp. immunoglobulin M. α2-macroglobulin n. a glycoprotein that inhibits proteases, found in vertebrate plasma.
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the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > types of
Russell body1892
precipitin1900
nephrotoxin1902
hepatotoxin1903
opsonin1903
autoantibody1905
concanavalin1917
isoantibody1919
reagin1925
immune globulin1934
macroglobulin1952
immunoglobulin1953
properdin1954
LATS1961
alloantibody1964
xenoantibody1974
monoclonal1980
abzyme1986
1952 J. Waldenström in Adv. Internal Med. 5 408 Pedersen compared this normally occurring macromolecule with the pathologic so-called ‘macroglobulin’ found in the disease described by us as macroglobulinemia.
1958 Chem. Abstr. 52 8326 α2-Macroglobulin..and γ-euglobulin..were freed from salt, isolated and characterized.
1966 Acta Chem. Scandinavica 20 2299 (title) The combining ratio between trypsin and serum α-2-macroglobulin.
1967 Times 21 Nov. 3/6 As well as these small antibody molecules, the body produces much larger antibodies, called macroglobulins.
1977 I. M. Roitt Essent. Immunol. (ed. 3) ii. 38 Often referred to as the macroglobulin antibodies because of their high molecular weight, IgM molecules are polymers of five 4-peptide subunits.
1983 D. J. Weatherall et al. Oxf. Textbk. Med. II. xix. 108/2 The presence of a macroglobulin may make the distinctiion from Waldenström's macroglobulinaemia difficult.
1994 Biochem. & Biophysical Res. Communications 203 1344 α2-Macroglobulin is not a heparin binding protein.
This entry has been updated (OED Third Edition, March 2000; most recently modified version published online March 2022).
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n.1952