melarsoproln.

Brit.

/mɛˈlɑːsə(ʊ)ˌprɒl/, U.S.

/mɛˈlɑrsəˌprɔl/,

/mɛˈlɑrsəˌprɑl/

Origin: Formed within English, by compounding. Etymons: melamine n., arsenic n., -o- connective, English -prol.

Etymology: < mel- (in melamine n.) + ars- (in arsenic n.) + -o- connective + -prol (probably pr- (in propyl n.) + -ol suffix, since the compound has been interpreted as a hydroxypropylene ester and has an alcohol group).

Pharmacology.

An organic arsenic compound, C₁₂H₁₅AsN₆OS₂, administered intravenously to treat late-stage African trypanosomiasis (sleeping sickness).

ΚΠ

1957 Approved Names (Gen. Med. Council) June (table) Melarsoprol.

1974 Trypanosomiasis & Leishmaniasis: Ciba Found. Symp. 1973 310 The problem of drug resistance has became of less importance since the discontinuance of tryparsamide for the treatment of established cases, and its replacement by melaminyl derivatives of arsenic such as melarsoprol.

1989 Lancet 3 June 1246/2 Morbidity and death associated with melarsoprol-induced encephalopathy was reduced in patients who were given prednisolone.

1998 Daily Tel. 17 June 19/2 Melarsopral [sic], an arsenic-based medicine, is injected into the bloodstream to annihilate the parasites.

This is a new entry (OED Third Edition, June 2001; most recently modified version published online March 2022).

单词	melarsoprol
释义	melarsoproln. Brit. /mɛˈlɑːsə(ʊ)ˌprɒl/, U.S. /mɛˈlɑrsəˌprɔl/, /mɛˈlɑrsəˌprɑl/ Origin: Formed within English, by compounding. Etymons: melamine n., arsenic n., -o- connective, English -prol. Etymology: < mel- (in melamine n.) + ars- (in arsenic n.) + -o- connective + -prol (probably pr- (in propyl n.) + -ol suffix, since the compound has been interpreted as a hydroxypropylene ester and has an alcohol group). Pharmacology. An organic arsenic compound, C₁₂H₁₅AsN₆OS₂, administered intravenously to treat late-stage African trypanosomiasis (sleeping sickness). ΚΠ 1957 Approved Names (Gen. Med. Council) June (table) Melarsoprol. 1974 Trypanosomiasis & Leishmaniasis: Ciba Found. Symp. 1973 310 The problem of drug resistance has became of less importance since the discontinuance of tryparsamide for the treatment of established cases, and its replacement by melaminyl derivatives of arsenic such as melarsoprol. 1989 Lancet 3 June 1246/2 Morbidity and death associated with melarsoprol-induced encephalopathy was reduced in patients who were given prednisolone. 1998 Daily Tel. 17 June 19/2 Melarsopral [sic], an arsenic-based medicine, is injected into the bloodstream to annihilate the parasites. This is a new entry (OED Third Edition, June 2001; most recently modified version published online March 2022). < n.1957
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