McCune–Albright syndromen.

Brit.

/məˈkjuːn ˈɔːlbrʌɪt ˈsɪndrəʊm/, U.S.

/məˈkjun ˈɔlˌbraɪt ˌsɪnˌdroʊm/,

/məˈkjun ˈɑlˌbraɪt ˌsɪnˌdroʊm/

Forms:

α. 1900s– McCune–Albright syndrome.

β. 1900s– McCune–Albright's syndrome (rare).

Origin: From proper names. Etymons: proper names McCune, Albright.

Etymology: < the names of Donovan J. McCune (1902–76), U.S. paediatrician, and Fuller Albright (1900–69), U.S. endocrinologist (see Albright n.). Compare Albright n. 1.

Medicine.

A disorder characterized by fibrous dysplasia of bones, patchy brown pigmentation of the skin, and endocrine dysfunction, esp. causing precocious puberty in girls. Also (and earlier) called Albright's syndrome.Cases of the syndrome were described independently by McCune in 1936 ( Amer. Jrnl. Dis. Children 52 743) and by Albright in 1937 (see Albright n. 1).

ΘΚΠ

the world > health and disease > ill health > a disease > diseases of tissue > disorders of bones > [noun] > other bone disorders

osteocachexy1857

osteitis deformans1877

Paget's disease1889

megalacria1891

osteochondritis dissecans1895

osteogenesis imperfecta1899

von Recklinghausen's disease1910

Albright's syndrome1940

fibrogenesis imperfecta ossium1952

pycnodysostosis1963

McCune–Albright syndrome1966

1966 Amer. Jrnl. Dis. Children 111 647/2 Sexual precocity, which forms part of the McCune-Albright syndrome in girls, is rarely noted in boys.

1968 Jrnl. Pediatrics 73 89 The syndrome is now known as McCune-Albright's syndrome or Albright's syndrome.

1993 Pediatric Radiol. 23 15/1 McCune-Albright syndrome is characterized by the triad of polyostotic fibrous dysplasia..,skin hyperpigmentation, and precocious puberty.

1998 Anticancer Res. 18 4415 Mutations that inhibit the GTPase activity of the a subunit of the stimulating G protein (Gsa) have been demonstrated in the myocardium of patients with McCune–Albright syndrome.

This entry has been updated (OED Third Edition, March 2001; most recently modified version published online March 2022).

单词	mccune–albright syndrome
释义	McCune–Albright syndromen. Brit. /məˈkjuːn ˈɔːlbrʌɪt ˈsɪndrəʊm/, U.S. /məˈkjun ˈɔlˌbraɪt ˌsɪnˌdroʊm/, /məˈkjun ˈɑlˌbraɪt ˌsɪnˌdroʊm/ Forms: α. 1900s– McCune–Albright syndrome. β. 1900s– McCune–Albright's syndrome (rare). Origin: From proper names. Etymons: proper names McCune, Albright. Etymology: < the names of Donovan J. McCune (1902–76), U.S. paediatrician, and Fuller Albright (1900–69), U.S. endocrinologist (see Albright n.). Compare Albright n. 1. Medicine. A disorder characterized by fibrous dysplasia of bones, patchy brown pigmentation of the skin, and endocrine dysfunction, esp. causing precocious puberty in girls. Also (and earlier) called Albright's syndrome.Cases of the syndrome were described independently by McCune in 1936 ( Amer. Jrnl. Dis. Children 52 743) and by Albright in 1937 (see Albright n. 1). ΘΚΠ the world > health and disease > ill health > a disease > diseases of tissue > disorders of bones > [noun] > other bone disorders osteocachexy1857 osteitis deformans1877 Paget's disease1889 megalacria1891 osteochondritis dissecans1895 osteogenesis imperfecta1899 von Recklinghausen's disease1910 Albright's syndrome1940 fibrogenesis imperfecta ossium1952 pycnodysostosis1963 McCune–Albright syndrome1966 1966 Amer. Jrnl. Dis. Children 111 647/2 Sexual precocity, which forms part of the McCune-Albright syndrome in girls, is rarely noted in boys. 1968 Jrnl. Pediatrics 73 89 The syndrome is now known as McCune-Albright's syndrome or Albright's syndrome. 1993 Pediatric Radiol. 23 15/1 McCune-Albright syndrome is characterized by the triad of polyostotic fibrous dysplasia..,skin hyperpigmentation, and precocious puberty. 1998 Anticancer Res. 18 4415 Mutations that inhibit the GTPase activity of the a subunit of the stimulating G protein (Gsa) have been demonstrated in the myocardium of patients with McCune–Albright syndrome. This entry has been updated (OED Third Edition, March 2001; most recently modified version published online March 2022). < n.1966
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