megalocyten.
/ˈmɛɡələ(ʊ)sʌɪt/, /ˈmɛɡl̩ə(ʊ)sʌɪt/, U.S. /ˈmɛɡ(ə)loʊˌsaɪt/, /ˈmɛɡ(ə)ləˌsaɪt/ Pathology.
1. An abnormally large erythrocyte; = macrocyte n. Now rare.
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the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > disorders of red cells > abnormal red cell
microcyte1876
megalocyte1886
macrocyte1889
megaloblast1890
gigantoblast1898
spherocyte1908
target cell1938
1886 Science 9 Apr. 321/1 In profound anaemia there will be found in the blood the normal red corpuscle,..and larger ones, known as megalocytes.
1889 D. J. Hamilton Text-bk. Pathol. I. 462 Giant blood corpuscles or megalocytes running up to 14 μ in diameter.
1929 R. B. H. Gradwohl tr. V. Schilling Blood Pictures ii. 113 Single or many large hyperchromatic cells (megalocytes, occasional megaloblasts).
1951 Q. Rev. Biol. 26 100/1 The erythrocytic series..gives rise to all normal and abnormal erythrocytes except megalocytes.
1980 Scand. Jrnl. Haematol. 24 299 It is assumed that these cells [sc. schistocytes] are fragments from the relatively few megalocytes which have reached the peripheral blood prior to medication.
2. Any of various other types of enlarged cell; esp. an enlarged hepatocyte, typical of pyrrolizidine alkaloid poisoning of livestock (cf. megalocytosis n.).
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1915 J. S. Dunkerley in Proc. Royal Physical Soc. Edinb. 1912–15 19 218 Union of micro- and megalo-cyte to form the binucleate sporoblast.
1944 Q. Rev. Biol. 19 222/1 Dunkerley has described the formation of the pansporoblast of Agarella gracilis by the production of ‘microcytes’ and ‘megalocytes’.
1975 Cancer Res. 35 2117 At 7 days after the hepatectomy many megalocytes could still be found in centrilobular zones.
1983 Proc. National Acad. Sci. U.S.A. 80 5087/2 (caption) Liver,.., containing a small focus of necrosis and an inclusion bearing megalocyte typical of cytomegalovirus infection.
1991 Jrnl. Nutrition 121 1869 High dietary iron resulted in greater sensitivity to GM [sc. gentamicin]..toxicity in terms of..increased mineralization, casts and megalocytes in renal tubules.
2000 Hepatology 32 312 The progressive loss of irreversibly injured megalocytes [in retrorsine-injured livers].
Derivatives
megaloˈcytic adj.
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1955 Austral. Vet. Jrnl. 31 40/1 Experimental work is in progress to test the hypothesis that the megalocytic change in the liver cells is brought about by the action of pyrrolizidine alkaloids on the metabolism of the cells.
1967 Amer. Jrnl. Clin. Pathol. 47 781/1 Megalocytic interstitial nephritis is a somewhat euphonic translation of the German term grosszellige-interstitielle Nephritis.
1975 Cancer Res. 35 1282 The typical oval cells and the megalocytic hepatocytes were not fluorescent.
1988 Amer. Jrnl. Vet. Res. 49 578/1 Megalocytic hepatopathy is the hallmark of PA [= pyrrolizidine alkaloid] toxicosis in horses.
1998 Acta Cytologica 42 1419 Renal malacoplakia may be related to megalocytic interstitial nephritis.
This entry has been updated (OED Third Edition, June 2001; most recently modified version published online March 2022).
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