megalocytosisn.
/ˌmɛɡələ(ʊ)sʌɪˈtəʊsɪs/, U.S. /ˌmɛɡələsaɪˈtoʊsɪs/ Pathology.
Abnormal enlargement of cells, spec. that seen in the liver as a result of pyrrolizidine alkaloid poisoning.
ΚΠ
1955 L. B. Bull in Austral. Vet. Jrnl. 31 35/1 The presence of large cells has been mentioned by some observers, but the true characteristic of the pathological change in the cells, for which we propose the term megalocytosis, appears to have been overlooked.
1970 Q. Rev. Biol. 45 67/2 The account of the Australian work is clear and useful where this deals with the authors' view of megalocytosis.
1977 Brit. Jrnl. Exper. Pathol. 58 663 After 2 doses the crypt epithelium showed megalocytosis and occasional abnormal mitotic figures.
1985 Science 2 Aug. 472/2 Many PA's are hepatotoxins and may cause an irreversible hemorrhagic necrosis, hepatic fibrosis, and megalocytosis.
1999 Jrnl. Hepatol. 31 1069 Diffuse megalocytosis (enlarged hepatocytes) was present in the group exposed to retrorsine.
This is a new entry (OED Third Edition, June 2001; most recently modified version published online March 2022).
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