methacholinen.

Brit.

/mɛθəˈkəʊliːn/, U.S.

/ˌmɛθəˈkoʊlin/

Origin: Formed within English, by compounding. Etymons: methyl n., English -a- , choline n.

Etymology: < meth- (in methyl n.: see note s.v. meth- comb. form) + -a- connective (compare -i- connective) + choline n.

Pharmacology.

A choline derivative with parasympathomimetic activity that can induce bronchoconstriction in asthmatics and is used in tests of airway responsiveness; O-acetyl-β-methylcholine, C₈H₁₈ClNO₂.

ΘΚΠ

the world > health and disease > healing > diagnosis or prognosis > tests > [noun] > materials used in testing

test-meal1891

mucicarmine1896

pastille1906

barium meal1913

barium enema1930

mecholyl1934

radioiodine1935

cardiolipin1942

histoplasmin1945

barium swallow1946

methacholine1948

radiotracer1949

piperoxan1950

radio pill1957

1948 Science 23 Jan. 96/2 Methyl on carbon, as in methacholine, apparently interferes with nicotinic action, whereas methyl on nitrogen is essential for nicotinic action.

1952 Jrnl. Amer. Med. Assoc. 17 May 271/1 The pharmacologic properties of methacholine chloride resemble those of acetylcholine, except for the less pronounced nicotinic effect on autonomic ganglions.

1961 A. Goth Med. Pharmacol. iv. 51 Bethanechol (Urecholine) and methacholine (Mecholyl) have many of the actions of acetylcholine on glands.

1987 D. J. Weatherall et al. Oxf. Textbk. Med. (ed. 2) II. xv. 78/2 Patients with asthma have similar responses to histamine and methacholine while normal subjects are more sensitive to histamine.

1993 Sci. Amer. Sept. 90/2 Compared with the bronchi of nonasthmatics, those of asthmatics contract in response to much lower doses of bronchoconstrictors (such as histamine or methacholine).

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	methacholine
释义	methacholinen. Brit. /mɛθəˈkəʊliːn/, U.S. /ˌmɛθəˈkoʊlin/ Origin: Formed within English, by compounding. Etymons: methyl n., English -a- , choline n. Etymology: < meth- (in methyl n.: see note s.v. meth- comb. form) + -a- connective (compare -i- connective) + choline n. Pharmacology. A choline derivative with parasympathomimetic activity that can induce bronchoconstriction in asthmatics and is used in tests of airway responsiveness; O-acetyl-β-methylcholine, C₈H₁₈ClNO₂. ΘΚΠ the world > health and disease > healing > diagnosis or prognosis > tests > [noun] > materials used in testing test-meal1891 mucicarmine1896 pastille1906 barium meal1913 barium enema1930 mecholyl1934 radioiodine1935 cardiolipin1942 histoplasmin1945 barium swallow1946 methacholine1948 radiotracer1949 piperoxan1950 radio pill1957 1948 Science 23 Jan. 96/2 Methyl on carbon, as in methacholine, apparently interferes with nicotinic action, whereas methyl on nitrogen is essential for nicotinic action. 1952 Jrnl. Amer. Med. Assoc. 17 May 271/1 The pharmacologic properties of methacholine chloride resemble those of acetylcholine, except for the less pronounced nicotinic effect on autonomic ganglions. 1961 A. Goth Med. Pharmacol. iv. 51 Bethanechol (Urecholine) and methacholine (Mecholyl) have many of the actions of acetylcholine on glands. 1987 D. J. Weatherall et al. Oxf. Textbk. Med. (ed. 2) II. xv. 78/2 Patients with asthma have similar responses to histamine and methacholine while normal subjects are more sensitive to histamine. 1993 Sci. Amer. Sept. 90/2 Compared with the bronchi of nonasthmatics, those of asthmatics contract in response to much lower doses of bronchoconstrictors (such as histamine or methacholine). This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1948
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