methadonen.

Brit.

/ˈmɛθədəʊn/, U.S.

/ˈmɛθəˌdoʊn/

Forms: 1900s– methadon, 1900s– methadone.

Origin: Formed within English, by compounding. Etymons: methyl n., amino- comb. form, di- comb. form, English heptanone.

Etymology: < meth- (in methyl n.: see note s.v. meth- comb. form) + a- (in amino- comb. form) + d- (in di- comb. form) + -one (in heptanone in the systematic name of the compound: compare -one suffix 1). Compare slightly earlier amidone n.

Pharmacology.

A synthetic opioid analgesic with longer-lasting and less sedative effects than those of morphine, which can be given orally and is used also in the treatment of opioid addiction; 6-dimethylamino-4,4-diphenyl-3-heptanone, (CH₃)₂N·CH(CH₃)·CH₂·C(C₆H₅)₂·CO·CH₂·CH₃.Proprietary names for this drug include Physeptone.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > analgesic > [noun] > other analgesics

Hoffmann's anodyne1747

acetylsalicylic acid1873

acetophenetidin1888

exalgin1889

pyramidon1898

aspirin1899

phenazone1899

Veganin1926

Trilene1935

Demerol1940

pethidine1942

Tridione1944

amidone1946

meperidine1947

methadone1947

Physeptone1947

Butazolidin1951

phenylbutazone1952

opioid1955

Panadol1955

propoxyphene1955

Tylenol1956

acetaminophen1957

paracetamol1957

Distalgesic1958

oxycodone1958

Sernyl1958

morphinomimetic1959

phencyclidine1959

levorphanol1960

mefenamic acid1962

pentazocine1964

Talwin1965

ibuprofen1967

nalbuphine1969

naproxen1971

phy1971

Nurofen1982

1947 Jrnl. Amer. Med. Assoc. 23 Aug. 1483 The Council voted to recognise the word Methadon as the generic designation for 6-dimethylamino-4,4-diphenyl-3-heptanone.

1948 Ann. N.Y. Acad. Sci. 51 17 It is not certain whether the Germans succeeded in the complete resolution of dl-methadone.

1952 W. T. Salter Textbk. Pharmacol. vi. 81/1 The danger of addiction of racemic methadon and levo-methadon is about equal to that of morphine.

1962 ‘K. Orvis’ Damned & Destroyed xxiii. 174 A new drug, methadon, is being used successfully as a reduction treatment... The patient starts regaining strength—moral and physical strength—almost at once.

1967 Martindale's Extra Pharmacopoeia (ed. 25) 783/1 Addiction to methadone is easier to treat than addiction to morphine.

1967 Martindale's Extra Pharmacopoeia (ed. 25) 800/2 Methadone hydrochloride may be used for the relief of severe pain of all types.

1971 Guardian 4 June 3/3 The aim of the methadone programme is to switch the mainliner's addiction from heroin to methadone, an addictive drug..which allows its addicts to lead a normal life... The methadone programme was begun in New York in 1965 by the Beth Israel Medical Centre.

1983 D. Stafford-Clark & A. C. Smith Psychiatry for Students (ed. 6) xiv. 214 A policy of transfer to prescribed methadone has not been very successful, as it creates methadone-dependent patients.

1994 Judicature Mar. 269/2 The treatment is more effective than other detoxification methods (such as use of drugs like methadone).

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	methadone
释义	methadonen. Brit. /ˈmɛθədəʊn/, U.S. /ˈmɛθəˌdoʊn/ Forms: 1900s– methadon, 1900s– methadone. Origin: Formed within English, by compounding. Etymons: methyl n., amino- comb. form, di- comb. form, English heptanone. Etymology: < meth- (in methyl n.: see note s.v. meth- comb. form) + a- (in amino- comb. form) + d- (in di- comb. form) + -one (in heptanone in the systematic name of the compound: compare -one suffix 1). Compare slightly earlier amidone n. Pharmacology. A synthetic opioid analgesic with longer-lasting and less sedative effects than those of morphine, which can be given orally and is used also in the treatment of opioid addiction; 6-dimethylamino-4,4-diphenyl-3-heptanone, (CH₃)₂N·CH(CH₃)·CH₂·C(C₆H₅)₂·CO·CH₂·CH₃.Proprietary names for this drug include Physeptone. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > analgesic > [noun] > other analgesics Hoffmann's anodyne1747 acetylsalicylic acid1873 acetophenetidin1888 exalgin1889 pyramidon1898 aspirin1899 phenazone1899 Veganin1926 Trilene1935 Demerol1940 pethidine1942 Tridione1944 amidone1946 meperidine1947 methadone1947 Physeptone1947 Butazolidin1951 phenylbutazone1952 opioid1955 Panadol1955 propoxyphene1955 Tylenol1956 acetaminophen1957 paracetamol1957 Distalgesic1958 oxycodone1958 Sernyl1958 morphinomimetic1959 phencyclidine1959 levorphanol1960 mefenamic acid1962 pentazocine1964 Talwin1965 ibuprofen1967 nalbuphine1969 naproxen1971 phy1971 Nurofen1982 1947 Jrnl. Amer. Med. Assoc. 23 Aug. 1483 The Council voted to recognise the word Methadon as the generic designation for 6-dimethylamino-4,4-diphenyl-3-heptanone. 1948 Ann. N.Y. Acad. Sci. 51 17 It is not certain whether the Germans succeeded in the complete resolution of dl-methadone. 1952 W. T. Salter Textbk. Pharmacol. vi. 81/1 The danger of addiction of racemic methadon and levo-methadon is about equal to that of morphine. 1962 ‘K. Orvis’ Damned & Destroyed xxiii. 174 A new drug, methadon, is being used successfully as a reduction treatment... The patient starts regaining strength—moral and physical strength—almost at once. 1967 Martindale's Extra Pharmacopoeia (ed. 25) 783/1 Addiction to methadone is easier to treat than addiction to morphine. 1967 Martindale's Extra Pharmacopoeia (ed. 25) 800/2 Methadone hydrochloride may be used for the relief of severe pain of all types. 1971 Guardian 4 June 3/3 The aim of the methadone programme is to switch the mainliner's addiction from heroin to methadone, an addictive drug..which allows its addicts to lead a normal life... The methadone programme was begun in New York in 1965 by the Beth Israel Medical Centre. 1983 D. Stafford-Clark & A. C. Smith Psychiatry for Students (ed. 6) xiv. 214 A policy of transfer to prescribed methadone has not been very successful, as it creates methadone-dependent patients. 1994 Judicature Mar. 269/2 The treatment is more effective than other detoxification methods (such as use of drugs like methadone). This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1947
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