metalationn.
/ˌmɛtəˈleɪʃn/, U.S. /ˌmɛdəˈleɪʃ(ə)n/ Chemistry.
The introduction of a metal atom into a compound; spec. the replacement of a hydrogen atom by a metal atom in an organic (usually aromatic) compound, forming a carbon-metal bond; an instance of this.
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metalation1934
1934 Gilman & Young in Jrnl. Amer. Chem. Soc. 56 1415/1 The term metalation is proposed for reactions involving replacement of hydrogen by a metal to give a true organometallic compound... Metalations were effected by metals, organometallic compounds and salts.
1957 E. G. Rochow et al. Chem. Organometallic Compounds iii. 54 Metalation reactions occur only with the derivatives of the strongly electropositive alkali and alkaline earth metals and, rarely, magnesium.
1968 R. O. C. Norman Princ. Org. Synthesis xi. 392 Electrophilic metalations by metal salts should not be confused with the metalation of aromatic compounds with metal.
1980 Chem. in Brit. Nov. 598/1 Metallation by RLi could conceivably produce the synthetically useful B9Cl8Li.
1992 Organometallics 11 1412/1 A careful optimization of the metalation procedure was first carried out.
This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).
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n.1934