metronidazolen.

Brit.

/ˌmɛtrəˈnʌɪdəzəʊl/, U.S.

/ˌmɛtrəˈnaɪdəˌzoʊl/

Origin: Formed within English, by compounding. Etymons: methyl n., nitro- comb. form, imidazole n.

Etymology: < me- (in methyl n.: see note s.v. meth- comb. form) + -tron- (perhaps < -tro- and -n- in nitro- comb. form) + -idazole (in imidazole n.).

Pharmacology.

An antibiotic given orally and by vaginal pessary in the treatment of infections with anaerobic bacteria or protozoans (e.g. giardiasis and trichomoniasis); 2-(2-methyl-5-nitroimidazol-1-yl)ethanol, C₆H₉N₃O₃.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > remedies for parasitic infections > [noun] > other internal parasiticides > specific drugs

phenanthridine1890

trypan red1905

trypan blue1911

tryparsamide1921

Bayer 2051922

stibophen1941

stilbamidine1941

suramin1941

mepacrine1943

PABA1943

metronidazole1960

stibocaptate1962

1960 Brit. Med. Jrnl. 24 Sept. 903/1 In an attempt to determine the clinical efficacy of metronidazole a trial was arranged in St. Mary's Hospital for Women, Manchester.

1965 I. M. Rollo in L. S. Goodman & A. Z. Gilman Pharmacol. Basis Therapeutics (ed. 3) liv. 1141/1 In 1959, Cosar and Julou reported the trichomonacidal activity..of 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole... Subsequent experience..has indicated that the oral administration of the drug, now called metronidazole, will cure a high proportion of infected individuals.

1974 R. M. Kirk et al. Surgery ii. 24 Symptomatic disease is treated with metronidazole..given orally.

1980 Brit. Med. Jrnl. 29 Mar. 882/2 In general metronidazole seems the most useful prophylactic for anaerobic organisms.

1998 Guardian 14 July ii. 13/2 She was treated with metronidazole, an anti-protozoal drug, which cleared up the infection in five days, and the other members of the family were tested for the presence of giardia cysts.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	metronidazole
释义	metronidazolen. Brit. /ˌmɛtrəˈnʌɪdəzəʊl/, U.S. /ˌmɛtrəˈnaɪdəˌzoʊl/ Origin: Formed within English, by compounding. Etymons: methyl n., nitro- comb. form, imidazole n. Etymology: < me- (in methyl n.: see note s.v. meth- comb. form) + -tron- (perhaps < -tro- and -n- in nitro- comb. form) + -idazole (in imidazole n.). Pharmacology. An antibiotic given orally and by vaginal pessary in the treatment of infections with anaerobic bacteria or protozoans (e.g. giardiasis and trichomoniasis); 2-(2-methyl-5-nitroimidazol-1-yl)ethanol, C₆H₉N₃O₃. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > remedies for parasitic infections > [noun] > other internal parasiticides > specific drugs phenanthridine1890 trypan red1905 trypan blue1911 tryparsamide1921 Bayer 2051922 stibophen1941 stilbamidine1941 suramin1941 mepacrine1943 PABA1943 metronidazole1960 stibocaptate1962 1960 Brit. Med. Jrnl. 24 Sept. 903/1 In an attempt to determine the clinical efficacy of metronidazole a trial was arranged in St. Mary's Hospital for Women, Manchester. 1965 I. M. Rollo in L. S. Goodman & A. Z. Gilman Pharmacol. Basis Therapeutics (ed. 3) liv. 1141/1 In 1959, Cosar and Julou reported the trichomonacidal activity..of 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole... Subsequent experience..has indicated that the oral administration of the drug, now called metronidazole, will cure a high proportion of infected individuals. 1974 R. M. Kirk et al. Surgery ii. 24 Symptomatic disease is treated with metronidazole..given orally. 1980 Brit. Med. Jrnl. 29 Mar. 882/2 In general metronidazole seems the most useful prophylactic for anaerobic organisms. 1998 Guardian 14 July ii. 13/2 She was treated with metronidazole, an anti-protozoal drug, which cleared up the infection in five days, and the other members of the family were tested for the presence of giardia cysts. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1960
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