methimazolen.
/mᵻˈθɪməzəʊl/, U.S. /məˈθɪməˌzoʊl/ Pharmacology.
An imidazole derivative that interferes with the synthesis of thyroid hormone and is given orally in the treatment of hyperthyroidism; 1-methylimidazole-2-thiol, C3H2N2(CH3)(SH).International Nonproprietary Name (1996): thiamazole.
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thyro-antitoxin1895
thiouracil1905
propylthiouracil1914
methylthiouracil1944
methimazole1951
thiamazole1971
1951 Amer. Jrnl. Med. Sci. 222 140/1 The relatively short period of methimazole therapy required to produce euthyroidism after initial iodine treatment.
1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 86 Thiouracil has been used to treat thyrotoxicosis but it is now replaced by methimazole and carbimazole.
1977 Lancet 21 May 1105/1 Treatment with 60 mg of methimazole and 60 mg propranolol daily resulted in a clearing of his psychotic and hypomanic symptoms.
1988 Jrnl. Neural Transmission 71 201 Desipramine binding was decreased in thyrotoxicosis and increased in rats treated with methimazole.
2000 Jrnl. Amer. Animal Hosp. Assoc. 36 215 Hyperthyroid cats were treated with methimazole until euthyroidism was achieved.
This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).
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n.1951